ID A0A0M4R9X2_9PSEU Unreviewed; 558 AA.
AC A0A0M4R9X2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Prenyltransferase {ECO:0000313|EMBL:ALE84951.1};
GN ORFNames=XF36_18915 {ECO:0000313|EMBL:ALE84951.1};
OS Pseudonocardia sp. HH130629-09.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1641402 {ECO:0000313|EMBL:ALE84951.1, ECO:0000313|Proteomes:UP000062082};
RN [1] {ECO:0000313|EMBL:ALE84951.1, ECO:0000313|Proteomes:UP000062082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HH130629-09 {ECO:0000313|EMBL:ALE84951.1,
RC ECO:0000313|Proteomes:UP000062082};
RX PubMed=26438860; DOI=10.1073/pnas.1515348112;
RA Sit C.S., Van Arnam E.B., Ramadhar T.R.;
RT "Variable genetic architectures produce virtually identical molecules in
RT bacterial symbionts of fungus-growing ants.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:13150-13154(2015).
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
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DR EMBL; CP011868; ALE84951.1; -; Genomic_DNA.
DR RefSeq; WP_060713005.1; NZ_CP011868.1.
DR AlphaFoldDB; A0A0M4R9X2; -.
DR KEGG; pseh:XF36_18915; -.
DR PATRIC; fig|1641402.3.peg.4056; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000062082; Chromosome.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 3.
DR InterPro; IPR001330; PFTB_repeat.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF00432; Prenyltrans; 2.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000062082};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:ALE84951.1}.
FT DOMAIN 23..168
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 387..525
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 558 AA; 59594 MW; BDBC23D420DAFAA9 CRC64;
MTPAHAGTGR LADEVSEAIA GGAEALLRSR RDDGVFDYGA DSLRSTLATA GAVTALHFAD
PGGTADLIAA GAARLRRTQT EDGGWAMVPG LPAEPGPTAV SAAALHLVDP AGSAEQVAAG
RRWMERYGGL AAIPHPEVVL WCRQFYGFVG WIAPADMRRF PLELALLPGL YRRLFDLRLP
MASALGLAQT RHRPLTRVQR TLSRLAEPNA LRVIRQTYEH EGSAGSWSED AWVTGLVCTG
LARAGVGQDM VDAAVGWLRR SMHPDGSWAT TPLDAAWTMY AVRGLVEAGY GDDERLVASR
DALLGLQQHR PFLAFGCPPG FWGWTAGRGW PAVLETGEIV SVLSRLPGTV QDSAVAEGVG
WLTDRQDSRG SWGLCVRNTR VANSGPCPTT TAQALDALLD AGVPADDRRV RRALRWLGRA
QLPGGGFESV WYREHTMGTA AVLETFARCG RGGDGPAVRA RALLERTRNP DGSWGDGHGA
PGTVEETGWA VAALLAAGAA PAEVEPAVRW LLAARLPDGG WPAEPVHEYV RRVSRYANPG
FTHGMALRAL GRYRKALT
//
