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Database: UniProt
Entry: A0A0M4RT96_LACPN
LinkDB: A0A0M4RT96_LACPN
Original site: A0A0M4RT96_LACPN 
ID   A0A0M4RT96_LACPN        Unreviewed;       311 AA.
AC   A0A0M4RT96;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 57.
DE   RecName: Full=Aspartate carbamoyltransferase {ECO:0000256|HAMAP-Rule:MF_00001};
DE            EC=2.1.3.2 {ECO:0000256|HAMAP-Rule:MF_00001};
DE   AltName: Full=Aspartate transcarbamylase {ECO:0000256|HAMAP-Rule:MF_00001};
DE            Short=ATCase {ECO:0000256|HAMAP-Rule:MF_00001};
GN   Name=pyrB {ECO:0000256|HAMAP-Rule:MF_00001,
GN   ECO:0000313|EMBL:ODO62442.1};
GN   ORFNames=ASV54_10915 {ECO:0000313|EMBL:APD01826.1}, AVR83_09110
GN   {ECO:0000313|EMBL:AOB23108.1}, AYO51_08595
GN   {ECO:0000313|EMBL:KYK51369.1}, C7M36_01966
GN   {ECO:0000313|EMBL:QHM37687.1}, IV39_GL002417
GN   {ECO:0000313|EMBL:KRN38685.1}, J8138_06140
GN   {ECO:0000313|EMBL:MBP5839009.1}, Lp19_1527
GN   {ECO:0000313|EMBL:KZU95573.1}, Lp90_2349
GN   {ECO:0000313|EMBL:KEZ13434.1}, LPJSA22_02456
GN   {ECO:0000313|EMBL:ODO62442.1}, LpLQ80_11640
GN   {ECO:0000313|EMBL:AWI41133.1}, Nizo2802_1179
GN   {ECO:0000313|EMBL:KZU54795.1};
OS   Lactiplantibacillus plantarum (Lactobacillus plantarum).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=1590 {ECO:0000313|EMBL:KRN38685.1, ECO:0000313|Proteomes:UP000051742};
RN   [1] {ECO:0000313|EMBL:KEZ13434.1, ECO:0000313|Proteomes:UP000028536}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lp90 {ECO:0000313|EMBL:KEZ13434.1,
RC   ECO:0000313|Proteomes:UP000028536};
RA   Lamontanara A., Caggianiello G., Orru L., Capozzi V., Michelotti V.,
RA   Bayjanov J.R., Renckens B., van Hijum S.A., Cattivelli L., Spano G.;
RT   "Noncontiguous-finished genome sequence of Lactobacillus plantarum strain
RT   Lp90 isolated from Apulian (Italy) wine.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KRN38685.1, ECO:0000313|Proteomes:UP000051742}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13273 {ECO:0000313|EMBL:KRN38685.1,
RC   ECO:0000313|Proteomes:UP000051742};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
RN   [3] {ECO:0000313|Proteomes:UP000183026}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MF1298 {ECO:0000313|Proteomes:UP000183026};
RA   McLeod A., Rud I., Axelsson L.;
RT   "Genome sequence of Lactobacillus plantarum MF1298, a candidate probiotic
RT   associated with unfavorable effect.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AOB23108.1, ECO:0000313|Proteomes:UP000093296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DF {ECO:0000313|EMBL:AOB23108.1,
RC   ECO:0000313|Proteomes:UP000093296};
RA   Petkau K., Fast D., Duggal A., Foley E.;
RT   "Comparative evaluation of the genomes of common bacterial members of the
RT   Drosophila intestinal community.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Proteomes:UP000076835, ECO:0000313|Proteomes:UP000076882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=19.1 {ECO:0000313|EMBL:KZU95573.1,
RC   ECO:0000313|Proteomes:UP000076882}, and Nizo2802
RC   {ECO:0000313|EMBL:KZU54795.1, ECO:0000313|Proteomes:UP000076835};
RA   Martino M.E.;
RT   "Comparative genomics of 54 Lactobacillus plantarum strains reveals genomic
RT   uncoupling from niche constraints.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:KYK51369.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2C2 {ECO:0000313|EMBL:KYK51369.1};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Proteomes:UP000075744}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2C2 {ECO:0000313|Proteomes:UP000075744};
RA   Suryavanshi M.V.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:ODO62442.1, ECO:0000313|Proteomes:UP000094892}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JSA22 {ECO:0000313|EMBL:ODO62442.1,
RC   ECO:0000313|Proteomes:UP000094892};
RA   Choi H.S.;
RT   "Genome sequencing of Lactobacillus plantarum JSA22, isolated from
RT   fermented soybean paste.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:QHM37687.1, ECO:0000313|Proteomes:UP000464882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SRCM101167 {ECO:0000313|EMBL:QHM37687.1,
RC   ECO:0000313|Proteomes:UP000464882};
RA   Jeong D.-Y.;
RT   "Lactobacillus plantatrum SRCM101167 having anti-virus activity species
RT   isolated from Korea kimchi.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:AWI41133.1, ECO:0000313|Proteomes:UP000244922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LQ80 {ECO:0000313|EMBL:AWI41133.1,
RC   ECO:0000313|Proteomes:UP000244922};
RA   Moriya N., Nakano K., Shiroma A., Shinzato M., Ashimine N., Minami M.,
RA   Tamotsu H., Shimoji M., Nakanishi T., Ohki S., Teruya K., Satou K.,
RA   Hirano T., Hagi T., Kobayashi M., Nomura M., Kimoto H.N., Tajima K.,
RA   Cai Y., Suzuki C.;
RT   "Complete Genome Sequence of Lactobacillus plantarum Strain LQ80 Selected
RT   for Preparation of Fermented Liquid Feed for Pig.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:APD01826.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MF1298 {ECO:0000313|EMBL:APD01826.1};
RA   McLeod A., Fagerlund A., Rud I., Axelsson L.;
RT   "Genome sequence of Lactobacillus plantarum MF1298, a candidate probiotic
RT   associated with unfavorable effect.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:MBP5839009.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=XSBN-10 {ECO:0000313|EMBL:MBP5839009.1};
RA   Du G.;
RT   "Study on Fermentation of lactic acid bacteria.";
RL   Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC         aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58228; EC=2.1.3.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001363, ECO:0000256|HAMAP-
CC         Rule:MF_00001};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       (S)-dihydroorotate from bicarbonate: step 2/3.
CC       {ECO:0000256|ARBA:ARBA00004852, ECO:0000256|HAMAP-Rule:MF_00001}.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. ATCase family. {ECO:0000256|HAMAP-Rule:MF_00001}.
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DR   EMBL; CP013753; AOB23108.1; -; Genomic_DNA.
DR   EMBL; CP013149; APD01826.1; -; Genomic_DNA.
DR   EMBL; CP028977; AWI41133.1; -; Genomic_DNA.
DR   EMBL; JIBX01000024; KEZ13434.1; -; Genomic_DNA.
DR   EMBL; JQAW01000024; KRN38685.1; -; Genomic_DNA.
DR   EMBL; LSST01000077; KYK51369.1; -; Genomic_DNA.
DR   EMBL; LUWZ01000029; KZU54795.1; -; Genomic_DNA.
DR   EMBL; LUXM01000026; KZU95573.1; -; Genomic_DNA.
DR   EMBL; JAGMWD010000004; MBP5839009.1; -; Genomic_DNA.
DR   EMBL; MCOL01000001; ODO62442.1; -; Genomic_DNA.
DR   EMBL; CP028334; QHM37687.1; -; Genomic_DNA.
DR   RefSeq; WP_011101888.1; NZ_WWDG01000002.1.
DR   GeneID; 77215929; -.
DR   KEGG; lpb:SH83_11385; -.
DR   PATRIC; fig|1590.142.peg.2445; -.
DR   OMA; FPTEREY; -.
DR   UniPathway; UPA00070; UER00116.
DR   Proteomes; UP000028536; Unassembled WGS sequence.
DR   Proteomes; UP000051742; Unassembled WGS sequence.
DR   Proteomes; UP000075744; Unassembled WGS sequence.
DR   Proteomes; UP000076835; Unassembled WGS sequence.
DR   Proteomes; UP000076882; Unassembled WGS sequence.
DR   Proteomes; UP000093296; Chromosome.
DR   Proteomes; UP000094892; Unassembled WGS sequence.
DR   Proteomes; UP000183026; Chromosome.
DR   Proteomes; UP000244922; Chromosome.
DR   Proteomes; UP000464882; Chromosome.
DR   Proteomes; UP000674860; Unassembled WGS sequence.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2.
DR   HAMAP; MF_00001; Asp_carb_tr; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR   InterPro; IPR002082; Asp_carbamoyltransf.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR   NCBIfam; TIGR00670; asp_carb_tr; 1.
DR   PANTHER; PTHR45753:SF6; ASPARTATE CARBAMOYLTRANSFERASE; 1.
DR   PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:APD01826.1};
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975, ECO:0000256|HAMAP-
KW   Rule:MF_00001};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00001}.
FT   DOMAIN          6..144
FT                   /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02729"
FT   DOMAIN          150..296
FT                   /note="Aspartate/ornithine carbamoyltransferase Asp/Orn-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF00185"
SQ   SEQUENCE   311 AA;  34712 MW;  C035D9D9281A5431 CRC64;
     MKTSQNLVSV EQFSNQDVMA YLKLAQAFKN GKTVQLSQPT FAMNLFFENS TRTHTSFEMA
     ERRLGLQVIP FDPKTSSVTK GESLLDTLKT IEAIGVNLAV VRHPRDRYYQ PLLDAGFDMS
     LINAGDGSGQ HPSQSLLDML TIYEEFGHFD GLKIAIVGDL AHSRVARSNM ALLTQLGAQV
     YFGGPKEWYG RDFEAYGEYQ TMDQLVATMD VMMLLRVQHE RLSQVNNQTF DASAYHQQYG
     LTAERAARMP KHAIIMHPAP VNRGVELASD LVEAPQSRIF QQMTNGVYIR MAMVASVLAH
     QGLISATQVE V
//
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