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Entry: A0A0M4SL11_9PROT
LinkDB: A0A0M4SL11_9PROT
Original site: A0A0M4SL11_9PROT 
ID   A0A0M4SL11_9PROT        Unreviewed;       436 AA.
AC   A0A0M4SL11;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   16-JAN-2019, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ALF46734.1};
GN   ORFNames=A3223_08475 {ECO:0000313|EMBL:ORI00421.1}, B9N61_07025
GN   {ECO:0000313|EMBL:OUT17647.1}, B9N66_07375
GN   {ECO:0000313|EMBL:OUT08741.1}, CCON33237_0001
GN   {ECO:0000313|EMBL:ALF46734.1}, TH67_09160
GN   {ECO:0000313|EMBL:OJJ27874.1};
OS   Campylobacter concisus.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=199 {ECO:0000313|EMBL:ALF46734.1, ECO:0000313|Proteomes:UP000066049};
RN   [1] {ECO:0000313|EMBL:OJJ27874.1, ECO:0000313|Proteomes:UP000183950}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMIT-JF1 {ECO:0000313|EMBL:OJJ27874.1,
RC   ECO:0000313|Proteomes:UP000183950};
RA   Huq M., Van T.T.H., Smooker P.M., Istivan T.S.;
RT   "Whole genome sequencing of Campylobacter concisus, an oral isolate
RT   from a Crohn's disease patient.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000066049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33237 {ECO:0000313|Proteomes:UP000066049};
RA   Miller W.G., Yee E., Chapman M.H., Huynh S., Bono J.L., On S.L.W.,
RA   St Leger J., Foster G., Parker C.T.;
RT   "Comparative genomics of the Campylobacter concisus group.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ALF46734.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 33237 {ECO:0000313|EMBL:ALF46734.1};
RA   Miller W.G., Yee E., Chapman M.H., Huynh S., Bono J.L., On S.L.W.,
RA   StLeger J., Foster G., Parker C.T.;
RT   "Comparative genomics of the Campylobacter concisus group.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000192388}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMIT-O17 {ECO:0000313|Proteomes:UP000192388};
RA   Huq M., Van T.T.H., Gurtler V., Elshagmani E., Allemailem K.S.,
RA   Smooker P.M., Istivan T.S.;
RT   "The ribosomal RNA operon (rrn) of Campylobacter concisus supports
RT   molecular typing to genomospecies level.";
RL   Gene Rep 6:8-14(2017).
RN   [5] {ECO:0000313|EMBL:OUT08741.1, ECO:0000313|Proteomes:UP000195261, ECO:0000313|Proteomes:UP000196534}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lasto205.94 {ECO:0000313|EMBL:OUT17647.1,
RC   ECO:0000313|Proteomes:UP000196534}, and Lasto64.99
RC   {ECO:0000313|EMBL:OUT08741.1, ECO:0000313|Proteomes:UP000195261};
RA   Cornelius A.J., Miller W.G., Lastovica A.J., On S.L., French N.P.,
RA   Vandenberg O., Biggs P.J.;
RT   "Complete genome of Campylobacter concisus ATCC 33237T and draft
RT   genomes for an additional eight well characterized C. concisus
RT   strains.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP012541; ALF46734.1; -; Genomic_DNA.
DR   EMBL; JXUP01000010; OJJ27874.1; -; Genomic_DNA.
DR   EMBL; LVLC01000030; ORI00421.1; -; Genomic_DNA.
DR   EMBL; NDYP01000007; OUT08741.1; -; Genomic_DNA.
DR   EMBL; NDYR01000010; OUT17647.1; -; Genomic_DNA.
DR   RefSeq; WP_054195855.1; NZ_PPCF01000095.1.
DR   EnsemblBacteria; ALF46734; ALF46734; CCON33237_0001.
DR   GeneID; 28661665; -.
DR   KEGG; ccoc:CCON33237_0001; -.
DR   PATRIC; fig|199.248.peg.1; -.
DR   KO; K02313; -.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000066049; Chromosome.
DR   Proteomes; UP000183950; Unassembled WGS sequence.
DR   Proteomes; UP000192388; Unassembled WGS sequence.
DR   Proteomes; UP000195261; Unassembled WGS sequence.
DR   Proteomes; UP000196534; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000066049,
KW   ECO:0000313|Proteomes:UP000183950, ECO:0000313|Proteomes:UP000192388,
KW   ECO:0000313|Proteomes:UP000195261};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      133    262       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      342    411       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     141    148       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   436 AA;  49721 MW;  507A6D20F7DEC104 CRC64;
     MIADEILENL STQISPEEYQ SYIKQLKFNE KASDDHIIVF TAPNELMAKF INTRYADKIA
     HLYEVRTGIK PNIEISSTKS SKVSKQNQIN VKQIKTQSSI LNPSYTFENF VCGASNQYAF
     LSAKAAAEKP GVLYNPLFIY GTTGLGKTHL LQSVGNHCLN KGKTVICVTS EQFMIDFTSH
     INNHSMPKFR EKYRNCDVLL IDDVQFLGKT DKIQEEFFNT YNELLAKNGQ IVMTSDRPPK
     TLKGFEDRMI SRFDKAFMAD ITPPELDTKI AIIIKKCEFD KIDLNKEVIN YIATNMGDNI
     REIEGAIINL NVFKTLMKEE ITLDLAKSIL KDLIKEKREN INFDTIVEIV SKELNIKQSD
     IKSKSRVTNI VEARRIIIYL AKMLTTNSMP QIANYFGMKD HSAVSHNIKK INELIQTNEI
     FSLKVTELKN KILTKG
//
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