ID A0A0M4THV2_9NOSO Unreviewed; 772 AA.
AC A0A0M4THV2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Sodium:calcium exchanger {ECO:0000313|EMBL:ALF51999.1};
GN ORFNames=ACX27_02650 {ECO:0000313|EMBL:ALF51999.1};
OS Nostoc piscinale CENA21.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=224013 {ECO:0000313|EMBL:ALF51999.1, ECO:0000313|Proteomes:UP000062645};
RN [1] {ECO:0000313|Proteomes:UP000062645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CENA21 {ECO:0000313|Proteomes:UP000062645};
RA Leao T.F., Leao P.N., Guimaraes P.I., de Melo A.G.C., Ramos R.T.J.,
RA Silva A., Fiore M.F., Schneider M.P.C.;
RT "Genome Of Nitrogen-Fixing Cyanobacterium Nostoc piscinale CENA21 From
RT Solimoes/Amazon River Floodplain Sediments And Comparative Genomics To
RT Uncover Biosynthetic Natural Products Potential.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ALF51999.1, ECO:0000313|Proteomes:UP000062645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CENA21 {ECO:0000313|EMBL:ALF51999.1,
RC ECO:0000313|Proteomes:UP000062645};
RX PubMed=27034496;
RA Leao T., Guimaraes P.I., de Melo A.G., Ramos R.T., Leao P.N., Silva A.,
RA Fiore M.F., Schneider M.P.;
RT "Draft Genome Sequence of the N2-Fixing Cyanobacterium Nostoc piscinale
RT CENA21, Isolated from the Brazilian Amazon Floodplain.";
RL Genome Announc. 4:0-0(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP012036; ALF51999.1; -; Genomic_DNA.
DR RefSeq; WP_062288047.1; NZ_CP012036.1.
DR AlphaFoldDB; A0A0M4THV2; -.
DR STRING; 224013.ACX27_02650; -.
DR PATRIC; fig|224013.5.peg.637; -.
DR OrthoDB; 9793589at2; -.
DR Proteomes; UP000062645; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR045158; KEA4/5/6-like.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR16254; POTASSIUM/PROTON ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR16254:SF30; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 417..539
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 581..666
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 679..748
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 772 AA; 83942 MW; 83866B4D681CC2FC CRC64;
MQEDFRLIVD LVSVLAVAAC GGLLASLLRQ PVLLGYLIGG MVVGPAGLGL IKEVIQVETL
AQFGVAFLLF ALGVEFSFAE LKKVKAIALG GGGLQIALTI LVTVVVCGVT GAWGSLPAKG
VFLGSILSLS STAVVLKCLM ERNETETPHG QVMLGILVVQ DLALGLMLAV LPALHAPAEV
IGVAVLTALV RICLFAAGAV VAGIWLIPPL LRMLARTESR ELFLLGVVAL CLGIALLTEY
LGLSIEMGAF VAGLMISEVE YADQTLTYVE PLRDIFASLF FAAIGMLIDP VFLWNNLELI
LGLVALVFVG KFLIITPLVK LFRYPLKTAL IAGFGLAQIG EFSFVLASEG QALGLVSRRI
YLLILGTTAV TLILTPFVLR LLPFLFNFAE SMPWLKPYLA GEGEARDVSE ELPVKDHIVV
CGYGRVGKNL VKLLQQHDLP VVVIDQSESR IQQLRDAGVA YVYGNCVSFH VLETAGVNHA
KGMAIALPDP MSTRLCLKRA LELHPELNLV VRATQDKNIE VLYQLGAREV VQPEFEASLE
MATYLLNDLG FSQFIVQREM QQIRNDHYLD LRPERSASEV SRDLDQATRD LNRRWYPLPA
TSPLIGMSLE EADMRYLTGV SLMAIRRANG TEIDYPNNLT KLEEGDRLLV VGASEELAAL
EEFAQGKIAV PGENSACQWI VVEADSPVDN KTLADLKNHE TSVRIQALRR DGKFIRRPDE
KTDLKVGDQV LLCGSLPSLN QLQSLFTAPN KMPLSIPIAK ASEAQTIKEF LS
//
