ID A0A0M4TZ77_9NOSO Unreviewed; 1504 AA.
AC A0A0M4TZ77;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:ALF56394.1};
GN Name=pscI {ECO:0000313|EMBL:ALF56394.1};
GN ORFNames=ACX27_14475 {ECO:0000313|EMBL:ALF56394.1};
OS Nostoc piscinale CENA21.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=224013 {ECO:0000313|EMBL:ALF56394.1, ECO:0000313|Proteomes:UP000062645};
RN [1] {ECO:0000313|Proteomes:UP000062645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CENA21 {ECO:0000313|Proteomes:UP000062645};
RA Leao T.F., Leao P.N., Guimaraes P.I., de Melo A.G.C., Ramos R.T.J.,
RA Silva A., Fiore M.F., Schneider M.P.C.;
RT "Genome Of Nitrogen-Fixing Cyanobacterium Nostoc piscinale CENA21 From
RT Solimoes/Amazon River Floodplain Sediments And Comparative Genomics To
RT Uncover Biosynthetic Natural Products Potential.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ALF56394.1, ECO:0000313|Proteomes:UP000062645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CENA21 {ECO:0000313|EMBL:ALF56394.1,
RC ECO:0000313|Proteomes:UP000062645};
RX PubMed=27034496;
RA Leao T., Guimaraes P.I., de Melo A.G., Ramos R.T., Leao P.N., Silva A.,
RA Fiore M.F., Schneider M.P.;
RT "Draft Genome Sequence of the N2-Fixing Cyanobacterium Nostoc piscinale
RT CENA21, Isolated from the Brazilian Amazon Floodplain.";
RL Genome Announc. 4:0-0(2016).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP012036; ALF56394.1; -; Genomic_DNA.
DR RefSeq; WP_062298344.1; NZ_CP012036.1.
DR STRING; 224013.ACX27_14475; -.
DR PATRIC; fig|224013.5.peg.3496; -.
DR OrthoDB; 499075at2; -.
DR Proteomes; UP000062645; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..435
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 946..1020
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1504 AA; 165190 MW; B6B0CAB38B328A6B CRC64;
MGISTSLNGS EIAVIGLSGR FPGAKNIDEF WQNLQQGKET IAFFTDEELL AAGINSSLLN
DPNYVKAQAI LDEAECFDAE FFGFNPREAT ITDPQHRVFL ECAWSALENA GYDSQSYPGA
IGVYAGSGMN TYLLNIYLNQ NIIGAIDPQQ LMLAGNKDFL TTRVSYKLNL EGPSYAVQTA
CSTSLVAVHL ACQSLLNGEC DMALAGGVAI TADRKTGYLY TEGGILSPDG HCRAFDADAQ
GTIGGEGVGI VVLKRLEDAL SDRDTIHAII KGSAINNDGA FKVSYTAPRI DTQAKVIKTA
QIVAEVEPET ITYIETHGTA TALGDPIEIA ALTQAFRSST QKTGFCAIGS VKTNIGHLDT
AAGVAGLIKT VLALKHKQIP PSLHYSAPNP EIDFANSPFY VNTKLTEWQT NNIPRRAGVS
SFGLGGTNAH VILEEAPAWD GGREQGRKYQ LLLLSAKTAS ALEKATTNLA DYLQAHPDLN
LADAAYTLLF GRRTFDYRRA VVCRDIPDAI KALQNSQPVA QKTQPRPVAF MFSGLGTHYV
DMALELYQTE STFRGCVDEC CELLEPLLNL DLRDVLYPNK NHQNGNQQTQ KGLDLRKMLG
RGGQSTDVAT QKLNQTVLTQ PAMFVIEYAL AQLWISWGIC PTAMIGYSIG EYVAATLAGV
LSLTDALTLV ARRAQMIDEL PTGAMLAVPL SESEIQPWLN EKISLSAING ESLCVVAGFP
DAVGELEQKL SDRGLIGKRL QTSHAFHSVM MEAIAPTFHN LVNQFSLKSP KIPYISNVTG
TWITAEQATD PTYWVQHLCQ TVRFADGVQQ LSQKDNPILL EVGPGQALIS FASQCLDKSL
MLPSLRYSYE QQSDVAYLLN TLGRLWQAGG AVDWSSFYTD APRQRIPLPT YPFERQRYWV
DAQPTANLVL RCAPGEQTNT IEETQTAPTT STTAYLRPNL DNDYVAPRTE VEQIIANIWQ
ELLGIAAVGV EDSFFELGGD SVLGIQVSAR ANKAGFRLTP QQLFEHQTIA KLAQVITKTQ
VVQAEQGVIT GSVPLTPAQH QFFALNQPET HHWNQAILLE VVKPLNLDIL EQTLKQLLIH
HDALRLRFTR SDSGWEQVNA APEEYVPLTY IDLSALSSTA QQSALEVAAA QIQASLNLTT
GPIVRFALFD MGVQQNSRLL IVIHHLGTDP GSWRILLEDL QTGYQQLSQG QPIQLPQKTT
SYQQWSLRLQ KYAASEQLQQ QQQHWLSGRY QQVATLPLDY PDGINTVASE AQVISVALNE
TETQLLLQEV PGVYRMNTQE VLLTALVQAF KQWTKQNLLL INLDENGREV STGGIDDVDI
SRTVGWITTT YPVLLDLDKT VNPGDALKAV KEQVRHASSN GIDYGVLRYL SPDSIVIEKF
QSLPQAEVMF LYLGQLSRSL PQDSLFKWTE EALGSTASPK AIRPYLFQIN AAITEGQLQL
YFNYSRNIHQ RQTVEKLSHN FVQALKSLIS HCQSPDAGDY TPSDFAAANI NQENLSKLLA
QISQ
//
