ID A0A0M5IZ14_DROBS Unreviewed; 1371 AA.
AC A0A0M5IZ14;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Tollo {ECO:0000313|EMBL:ALC44674.1};
GN ORFNames=Dbus_chr3Lg1840 {ECO:0000313|EMBL:ALC44674.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC44674.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC44674.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC44674.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; CP012525; ALC44674.1; -; Genomic_DNA.
DR RefSeq; XP_017843545.1; XM_017988056.1.
DR STRING; 30019.A0A0M5IZ14; -.
DR GeneID; 108600462; -.
DR OMA; WSTMSLE; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000494163; Chromosome 3l sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0040011; P:locomotion; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 8.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR45617; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR PANTHER; PTHR45617:SF142; SI:DKEY-90M5.4; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 11.
DR SMART; SM00369; LRR_TYP; 25.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 4.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1371
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005803384"
FT TRANSMEM 1019..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1074..1209
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1235..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1371 AA; 156150 MW; 6E3B25B567D73748 CRC64;
MLASHMLYVL IASCAMPIFG AALSKTVLYQ APDDCRWSGG GETDITLVCH LRTINSELEN
TNFSVIQPHN TVRLRLECND ALFFQSSLSP DSFRSLVELR DLTIEYCKLG NLTEGSFRGL
QELRNLTIRT HNGDWSTMSL EMASNSFVEF RQLERLDLSL NNIWLIPDGM VCPLKSLQHL
NASYNKIQDI SNFYFSASLS SRKSRVCGAT LQSLDLSANK MVSLPSAMLS ALVRLQQLNM
ARNSMSFLAD RAFEGLLSLR IVDLSANRLT SLPPELFAET KQLQEIYLRN NSINVLAPGI
FGELSELLVL DLANNELNSQ WINAATFVGL KQLMLLDLSA NKISRLEAHM FRPLASLQLL
KLEGNYIDQL PAGIFAELSA LHTLILSRNR ISVIEQRTLQ GLPNLQVLSL DYNRISSLHP
RALVNCSQLQ DLHLNDNKLQ VVPEALLHVP LLKTLDVGEN LITQLENTSI TQLENLYGLR
MTENGMTELR RGVFERMSSL QILNLSGNKL KSIEAGALQR NTQLQAIRLD GNQLTHIAGL
FTDLPNLVWL NMSGNRLEQF DYAHIPKCLQ WLDVRANRIR QLSNYLEYDN ELSLSTFDAS
YNLLTELTAS SLPNSIEVLY LNDNLINKIQ PYTFFKKPNL TRVDLVRNKL TTLEPNALRL
SPIAEERALP EFYIGQMAYV CDCQLDWLQK LNRESRTQPQ LMDLDQIYCK LTYARGATQL
TLLEAKAHDF LCKYESHCFA LCHCCDFQAC DCKMECPDRC SCYHDQSWTS NVVDCSRADY
ARTLPAHIPM DATQLYLDGN TFTELQSHAF IGRKRLKVLH LNHSRIETLH NRTFYGLLEL
EVLQLQHNAL RALQGNEFQG LDNLQELYLQ HNAIASIDTL TFTHLYHLKI LRLDHNAIGN
FAVWNFLPSY LNELRLAGNP WSCRCEFIDK LRDYLARHEH VQDRQQLHCL LPGNSTQMSI
YASDSLPLVQ CSQTLQLGLD TNYKWSGNVL ENGAAAEQPL AGNATSTKMI LTPPPKQEYI
PILLAILTAF IFIIICTLLV FIFRQQMRVW CHARFGVRLF YNAQKDVDKN EREKLFDAFI
SYSSKDELFV NEQLAPMLEL GEQRYKLCLH QRDFPIGGYL PETIVQAIDS SRRTIMVVSE
NFIKSEWCRF EFKSAHQSVL RDRRRRLIVI VLGEVPQKEL DPDLRLYLKT NTYLQWGDKL
FWQKLRFALP DVSHASHATR AVAPCHAPIN HAAYHHHHHL HQQQQQQQQQ QQQMLHPHAH
PHPHHHQQQF MLPPPPNALQ PGSFRRQPST QQQHRNNNIN NNNNNQQQQQ QQQQQQQQAA
LLMGGNGGAC GVGVAAPQMI PLAGGIQQQS LPLPPTAAAS QPTPAARNLH M
//