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Database: UniProt
Entry: A0A0M5IZ14_DROBS
LinkDB: A0A0M5IZ14_DROBS
Original site: A0A0M5IZ14_DROBS 
ID   A0A0M5IZ14_DROBS        Unreviewed;      1371 AA.
AC   A0A0M5IZ14;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Tollo {ECO:0000313|EMBL:ALC44674.1};
GN   ORFNames=Dbus_chr3Lg1840 {ECO:0000313|EMBL:ALC44674.1};
OS   Drosophila busckii (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC44674.1, ECO:0000313|Proteomes:UP000494163};
RN   [1] {ECO:0000313|EMBL:ALC44674.1, ECO:0000313|Proteomes:UP000494163}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Whole larvae {ECO:0000313|EMBL:ALC44674.1};
RA   Zhou Q., Bachtrog D.;
RT   "Ancestral chromatin configuration constrains chromatin evolution on
RT   differentiating sex chromosomes in Drosophila.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; CP012525; ALC44674.1; -; Genomic_DNA.
DR   RefSeq; XP_017843545.1; XM_017988056.1.
DR   STRING; 30019.A0A0M5IZ14; -.
DR   GeneID; 108600462; -.
DR   OMA; WSTMSLE; -.
DR   OrthoDB; 927694at2759; -.
DR   Proteomes; UP000494163; Chromosome 3l sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0040011; P:locomotion; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 8.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR45617; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR   PANTHER; PTHR45617:SF142; SI:DKEY-90M5.4; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   Pfam; PF13855; LRR_8; 6.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00364; LRR_BAC; 8.
DR   SMART; SM00365; LRR_SD22; 11.
DR   SMART; SM00369; LRR_TYP; 25.
DR   SMART; SM00082; LRRCT; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 4.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 6.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1371
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005803384"
FT   TRANSMEM        1019..1043
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1074..1209
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          1235..1320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1351..1371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1282..1320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1371 AA;  156150 MW;  6E3B25B567D73748 CRC64;
     MLASHMLYVL IASCAMPIFG AALSKTVLYQ APDDCRWSGG GETDITLVCH LRTINSELEN
     TNFSVIQPHN TVRLRLECND ALFFQSSLSP DSFRSLVELR DLTIEYCKLG NLTEGSFRGL
     QELRNLTIRT HNGDWSTMSL EMASNSFVEF RQLERLDLSL NNIWLIPDGM VCPLKSLQHL
     NASYNKIQDI SNFYFSASLS SRKSRVCGAT LQSLDLSANK MVSLPSAMLS ALVRLQQLNM
     ARNSMSFLAD RAFEGLLSLR IVDLSANRLT SLPPELFAET KQLQEIYLRN NSINVLAPGI
     FGELSELLVL DLANNELNSQ WINAATFVGL KQLMLLDLSA NKISRLEAHM FRPLASLQLL
     KLEGNYIDQL PAGIFAELSA LHTLILSRNR ISVIEQRTLQ GLPNLQVLSL DYNRISSLHP
     RALVNCSQLQ DLHLNDNKLQ VVPEALLHVP LLKTLDVGEN LITQLENTSI TQLENLYGLR
     MTENGMTELR RGVFERMSSL QILNLSGNKL KSIEAGALQR NTQLQAIRLD GNQLTHIAGL
     FTDLPNLVWL NMSGNRLEQF DYAHIPKCLQ WLDVRANRIR QLSNYLEYDN ELSLSTFDAS
     YNLLTELTAS SLPNSIEVLY LNDNLINKIQ PYTFFKKPNL TRVDLVRNKL TTLEPNALRL
     SPIAEERALP EFYIGQMAYV CDCQLDWLQK LNRESRTQPQ LMDLDQIYCK LTYARGATQL
     TLLEAKAHDF LCKYESHCFA LCHCCDFQAC DCKMECPDRC SCYHDQSWTS NVVDCSRADY
     ARTLPAHIPM DATQLYLDGN TFTELQSHAF IGRKRLKVLH LNHSRIETLH NRTFYGLLEL
     EVLQLQHNAL RALQGNEFQG LDNLQELYLQ HNAIASIDTL TFTHLYHLKI LRLDHNAIGN
     FAVWNFLPSY LNELRLAGNP WSCRCEFIDK LRDYLARHEH VQDRQQLHCL LPGNSTQMSI
     YASDSLPLVQ CSQTLQLGLD TNYKWSGNVL ENGAAAEQPL AGNATSTKMI LTPPPKQEYI
     PILLAILTAF IFIIICTLLV FIFRQQMRVW CHARFGVRLF YNAQKDVDKN EREKLFDAFI
     SYSSKDELFV NEQLAPMLEL GEQRYKLCLH QRDFPIGGYL PETIVQAIDS SRRTIMVVSE
     NFIKSEWCRF EFKSAHQSVL RDRRRRLIVI VLGEVPQKEL DPDLRLYLKT NTYLQWGDKL
     FWQKLRFALP DVSHASHATR AVAPCHAPIN HAAYHHHHHL HQQQQQQQQQ QQQMLHPHAH
     PHPHHHQQQF MLPPPPNALQ PGSFRRQPST QQQHRNNNIN NNNNNQQQQQ QQQQQQQQAA
     LLMGGNGGAC GVGVAAPQMI PLAGGIQQQS LPLPPTAAAS QPTPAARNLH M
//
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