ID A0A0M5J778_DROBS Unreviewed; 423 AA.
AC A0A0M5J778;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Egr {ECO:0000313|EMBL:ALC41536.1};
GN ORFNames=Dbus_chr2Rg1115 {ECO:0000313|EMBL:ALC41536.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC41536.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC41536.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC41536.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; CP012524; ALC41536.1; -; Genomic_DNA.
DR RefSeq; XP_017835697.1; XM_017980208.1.
DR AlphaFoldDB; A0A0M5J778; -.
DR SMR; A0A0M5J778; -.
DR STRING; 30019.A0A0M5J778; -.
DR GeneID; 108595063; -.
DR OMA; LVYAQIH; -.
DR OrthoDB; 5403423at2759; -.
DR Proteomes; UP000494163; Chromosome 2r sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 281..423
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 156..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 48130 MW; 1F4FAA7F8B3378C0 CRC64;
MTAETLKPFI TPTSAVNNFP AKQPASVTHS QRRSKQLIPI VLSSIGVLLV IGIFSLTIWQ
TTRVKQLENN LNSLQREVNS LRQRLGINYL EDLAEFQKEY ANLLIHDPSK LDDIESEDDD
LEYEAGMDDV DDEDDEDGGN ENTDYDEYLD LVKQEKASTQ QTTLQTSTDE NEAVGSTSSA
SNDDNVFDDF TSYNESKRKR KERKSRSIAE LSHELHNNKL TELKLNKTEQ TAETAAAQTH
AKKSRQRSRQ SRNQRLLIRK SDSTVSAKSI DSNAMTTSSP AAHFHLNRKL SHHEAPIKMH
SYQGDMYIGQ ATASSENQWE QHFSVNNGVL TVLQPGLYYI YAQICYNNTH DQNGFIIFHG
QNAFLQCLNT VPTNMPQKVH TCHTSGLIQL QQNESIHLRD IHRDRNVMLR EDNNRSYFGI
IKV
//
