ID A0A0M5JLL9_9GAMM Unreviewed; 438 AA.
AC A0A0M5JLL9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=fumarylacetoacetase {ECO:0000256|ARBA:ARBA00012094};
DE EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
GN ORFNames=AMQ28_13605 {ECO:0000313|EMBL:ALD03282.1};
OS Acinetobacter sp. TTH0-4.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1646498 {ECO:0000313|EMBL:ALD03282.1, ECO:0000313|Proteomes:UP000055186};
RN [1] {ECO:0000313|EMBL:ALD03282.1, ECO:0000313|Proteomes:UP000055186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTH0-4 {ECO:0000313|EMBL:ALD03282.1,
RC ECO:0000313|Proteomes:UP000055186};
RA Zhang G.;
RT "Acinetobacter qinghaiensis sp. nov., isolated from active layer of
RT permafrost region.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC {ECO:0000256|ARBA:ARBA00004782}.
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DR EMBL; CP012608; ALD03282.1; -; Genomic_DNA.
DR RefSeq; WP_053580080.1; NZ_CP012608.1.
DR AlphaFoldDB; A0A0M5JLL9; -.
DR STRING; 1646498.AMQ28_13605; -.
DR KEGG; att:AMQ28_13605; -.
DR PATRIC; fig|1646498.3.peg.2734; -.
DR UniPathway; UPA00139; UER00341.
DR Proteomes; UP000055186; Chromosome.
DR GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR005959; Fumarylacetoacetase.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR InterPro; IPR015377; Fumarylacetoacetase_N.
DR InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR Pfam; PF09298; FAA_hydrolase_N; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 20..122
FT /note="Fumarylacetoacetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09298"
FT DOMAIN 129..398
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 438 AA; 48935 MW; F63156C192A2D472 CRC64;
MTGQLKSFIE VAQDSDFPIQ NLPFGVFSQS REGKRRVGVA LGEWVVDLAA LEANGCLNLH
PNENYFNQST LNTFIESGKS NWSKLRAELQ NLLSADNPEL RDNLVLRDQV FFKQSDVILH
LPVHIPGYTD FYSSKEHATN VGCMFRDPKN ALLANWSELP VGYNGRASSV IVSGTDVVRP
SGQIKLPNSE RPEFSACRKL DFELETGFIV GKANRLGEPV SIENAWDHIF GMVLFNDWSA
RDLQQWEYVP LGPFNAKTFA SSISPWIVTM EALEPFKTHS PTQEPQPLHY LREDHANNSY
DIHLSVELKA KNAEHADVIS QTNFKYMYWS MAQQLTHHTI AGCNLQVGDL MGSGTISGPT
PESYGSLLEI TWNSSKPLTL SNGEQRSFIQ DGDTLIMKGY CQKEGLRIGF GEVSGKVLPA
IQFNFTAHTA EEKLSETV
//
