ID A0A0M6L0N1_TURTR Unreviewed; 230 AA.
AC A0A0M6L0N1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Growth hormone A1 {ECO:0000313|EMBL:CDW51464.1};
DE SubName: Full=Prolactin isoform X1 {ECO:0000313|RefSeq:XP_019800535.1};
GN Name=GHA1 {ECO:0000313|EMBL:CDW51464.1};
GN Synonyms=PRL {ECO:0000313|RefSeq:XP_019800535.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|EMBL:CDW51464.1};
RN [1] {ECO:0000313|EMBL:CDW51464.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26697363; DOI=10.1016/j.gdata.2015.09.007;
RA Premzl M.;
RT "Third party data gene data set of eutherian growth hormone genes.";
RL Genom Data 6:166-169(2015).
RN [2] {ECO:0000313|EMBL:CDW51464.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26862561; DOI=10.1016/j.dib.2015.11.056;
RA Premzl M.;
RT "Curated eutherian third party data gene data sets.";
RL Data Brief 6:208-213(2016).
RN [3] {ECO:0000313|EMBL:CDW51464.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [4] {ECO:0000313|RefSeq:XP_019800535.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019800535.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003618}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000256|ARBA:ARBA00008474, ECO:0000256|RuleBase:RU003618}.
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DR EMBL; LM644217; CDW51464.1; -; mRNA.
DR RefSeq; XP_019800535.1; XM_019944976.1.
DR STRING; 9739.ENSTTRP00000015367; -.
DR GeneID; 101335385; -.
DR OMA; NEVYSRW; -.
DR OrthoDB; 4765458at2759; -.
DR Proteomes; UP000245320; Chromosome 10.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR GO; GO:0038161; P:prolactin signaling pathway; IEA:Ensembl.
DR CDD; cd10288; prolactin_like; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417:SF5; PROLACTIN; 1.
DR PANTHER; PTHR11417; SOMATOTROPIN,PROLACTIN; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hormone {ECO:0000256|RuleBase:RU003618};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601400-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PIRSR:PIRSR601400-1}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..230
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041120789"
FT BINDING 58
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR601400-1"
FT BINDING 214
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR601400-1"
SQ SEQUENCE 230 AA; 26017 MW; 572039BB8728C4CD CRC64;
MDNKGSSQKA GSLLLLLLLV SNLLLCKSVA SLPICPSGAV NCQVSLRDLF DRAVILSHYI
HNLSSEMFNE FDKRYAQGRG FITKAINSCH TSSLSTPEDK EQAQQVHHEV LLSMILGVLR
SWNDPLYHLV TEVRGMQEAP ESILSRAIEI EEQNKRLLEG MEKIVGQVHP GVKENEVYSV
WSGLPSLQMA DEDTRLFAFY NLLHCLRRDS HKIDSYLKLL KCRIIYDSNC
//
