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Database: UniProt
Entry: A0A0M6ZVB0_9RHOB
LinkDB: A0A0M6ZVB0_9RHOB
Original site: A0A0M6ZVB0_9RHOB 
ID   A0A0M6ZVB0_9RHOB        Unreviewed;       469 AA.
AC   A0A0M6ZVB0;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   16-JAN-2019, entry version 15.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   Name=algD {ECO:0000313|EMBL:CTQ74465.1};
GN   ORFNames=LA5096_04058 {ECO:0000313|EMBL:CTQ74465.1};
OS   Labrenzia alba.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Labrenzia.
OX   NCBI_TaxID=311410 {ECO:0000313|EMBL:CTQ74465.1, ECO:0000313|Proteomes:UP000049983};
RN   [1] {ECO:0000313|EMBL:CTQ74465.1, ECO:0000313|Proteomes:UP000049983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 5096 {ECO:0000313|EMBL:CTQ74465.1,
RC   ECO:0000313|Proteomes:UP000049983};
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; CXWC01000011; CTQ74465.1; -; Genomic_DNA.
DR   RefSeq; WP_055112293.1; NZ_CXWE01000001.1.
DR   EnsemblBacteria; CTQ74465; CTQ74465; LA5096_04058.
DR   OrthoDB; 647136at2; -.
DR   Proteomes; UP000049983; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000049983};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124,
KW   ECO:0000313|EMBL:CTQ74465.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000049983}.
FT   DOMAIN      342    457       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    293    293       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      55     55       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      60     60       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     111    111       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     186    186       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     296    296       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     356    356       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   469 AA;  50638 MW;  8D34AC0103807D65 CRC64;
     MNMFVGRLDT AQKLDSVSLR LVEQKKAISV VGLGYVGAVS LACLSDLGHR VVGTDIDNQK
     VDSIAWGQSP IHEDRLGELL SKGVAEDLLH ATTNLERAVL ETDVTFVSVG TPTSEDGGCD
     TRAIEAVARG IGEALAKKDG FHIVVLRCSV PPGTTLDIMK PVLEQYSNKV AGKDFGICFN
     PEFLREGTAI ADFHAPPKTV IGVSDQKTAD VLAEIYAPVD ESPIVTTVEV AELVKYVDNV
     WHATKVCFAN EVGRLCKPMG IDSHAVMDIF VQDTKLNLSP YYLKPGFAFG GSCLPKEVRA
     VTHLAEKLGV ATPLMDSLTP SNEKQIDQAI GMIRETGAKK VAVLGVAFKP GTDDLRESPA
     LELISELQRD GIEVVAYDPA IQPGPHIAQQ FEYMRYAAPH LQEVVDGLAG FMKSTPKSAI
     RDADAIIVTQ KLPELRSVLR SKKEEATVVD LVRISAEVPN SSHYIGIGW
//
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