ID A0A0M8MJF6_9BASI Unreviewed; 1152 AA.
AC A0A0M8MJF6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Cnh-domain-containing protein {ECO:0000313|EMBL:KOS12758.1};
GN ORFNames=Malapachy_1345 {ECO:0000313|EMBL:KOS12758.1};
OS Malassezia pachydermatis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=77020 {ECO:0000313|EMBL:KOS12758.1, ECO:0000313|Proteomes:UP000037751};
RN [1] {ECO:0000313|EMBL:KOS12758.1, ECO:0000313|Proteomes:UP000037751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 1879 {ECO:0000313|EMBL:KOS12758.1,
RC ECO:0000313|Proteomes:UP000037751};
RA Triana S., Ohm R., Gonzalez A., DeCock H., Restrepo S., Celis A.;
RT "Draft Genome Sequence of Malassezia furfur CBS1878 and Malassezia
RT pachydermatis CBS1879.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS12758.1}.
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DR EMBL; LGAV01000009; KOS12758.1; -; Genomic_DNA.
DR RefSeq; XP_017990390.1; XM_018135850.1.
DR AlphaFoldDB; A0A0M8MJF6; -.
DR STRING; 77020.A0A0M8MJF6; -.
DR GeneID; 28727725; -.
DR VEuPathDB; FungiDB:Malapachy_1345; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000037751; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000037751}.
FT DOMAIN 339..526
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 722..1017
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 129542 MW; D150B5367F18D856 CRC64;
MDQSQSRASS RGESTPSPTH VLRRMQSALL PGERQMSAFQ QPTSTPDAFT TVTDPVTTRA
SVSPGSSEFP PPRVSSQLVR HESPAPIVHG ADLASSTRPM PVLLPGDRPV NPALLSDVAR
ALENAVVPTN RTKNELTYAR AFDGQETVDK LMEIARTRHR DLALLLGRAL DAQKFFHDVT
YDHRLRDSQS ELYQFYYDRW GPHIDGEAFA LTTPAASRRN SSSTAAGRPT LTALDMERVY
SAQNALAIDD ADEKEAQTYH PEYPIGVFTP LTSCYSPTCQ PGQPCYSYAC PNNRVELTSV
QSTLQREDSH EGLNEITTQL WAESVPKEIY NQVPDMERKR QEVIFEIIST ERAYVQDLEY
LRDIWIKPLS TQHILSESRR DGFVEKVFCN LLEILAVNAR LSEMLMRRQR HHAVIDHIGD
IFVEFVREFD PYVKYGANQA AARLAVEAEK SSNPIFAMFA ADTERKAVSR KLELNGYLTK
PTTRLARYPL LFEQMLKFTA ESNVDKMILP KVIQQIQRLL THVNDETGRS ENRLQLTFLS
RHLVFKPLDM VDLRLNEEGR ELVFKNALKK RGTQSDSSEI QLYLFDHALL MVKVKIVHKA
EVFRVYRRPI PLEFLQVTVY DDVQTSKGIK TRSVLSRSSI GKRTSIGAMP GQTLPKQDSK
SGYAITFAHL GKRGYHITLW STTMANRSKW LEHVEMRQEI LQNRSRIFDM IPVAPGMMDV
PTNRITCAVP FDFCRQIFFG REDGVYLANV RDDTHPPKLV LALPGVTQVD VLEEFQILIV
LAEQVVHTFT LNALDPADPV MSLKRGRRIA SHTSFFRAGV CMGRTLVCVV KSGPVSSTIK
TLEPIEYSLR AKKQQTFRKL LQGGQDTLRV FKEFYIPTES SSIHFLKSKL CIGTTKGFEI
VDLETLETQG LLDPADQSLD FVQRRENLKA IAIYRIEGEF LLCYNEFAFY VNKNGWRAKG
NWIIHWEGNP TSFALHYPYI LAFESNFIEV RHVETGALHQ VITGFNLRCL FADTFSASIQ
SRSYNHRLQK MGYANPMRTN SMPVQQVTVA PPNIVGSPAA ASMTAAMGGI QTPVVPPGTM
SDGSSPYNSP RLSFSYGSPL SLQSQSFGPL VQSPPNMTSG TAQSSVLESV LASRSEILFV
GDSSAYAIRP HT
//
