ID A0A0M8MMH2_9BASI Unreviewed; 894 AA.
AC A0A0M8MMH2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=Malapachy_0674 {ECO:0000313|EMBL:KOS14538.1};
OS Malassezia pachydermatis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=77020 {ECO:0000313|EMBL:KOS14538.1, ECO:0000313|Proteomes:UP000037751};
RN [1] {ECO:0000313|EMBL:KOS14538.1, ECO:0000313|Proteomes:UP000037751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 1879 {ECO:0000313|EMBL:KOS14538.1,
RC ECO:0000313|Proteomes:UP000037751};
RA Triana S., Ohm R., Gonzalez A., DeCock H., Restrepo S., Celis A.;
RT "Draft Genome Sequence of Malassezia furfur CBS1878 and Malassezia
RT pachydermatis CBS1879.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS14538.1}.
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DR EMBL; LGAV01000003; KOS14538.1; -; Genomic_DNA.
DR RefSeq; XP_017992170.1; XM_018135189.1.
DR AlphaFoldDB; A0A0M8MMH2; -.
DR STRING; 77020.A0A0M8MMH2; -.
DR GeneID; 28727064; -.
DR VEuPathDB; FungiDB:Malapachy_0674; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000037751; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 3.90.1280.20; -; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711:SF9; ANION_PROTON EXCHANGE TRANSPORTER GEF1; 1.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000037751};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 75..93
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 105..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 259..281
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 324..345
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 357..374
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 395..414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 434..451
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 486..507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 513..534
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 562..585
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 769..825
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 894 AA; 98341 MW; 2221B36676BB30EE CRC64;
MAMPLRPPAP AREATKDYGR FTTVDWVVDG RRERVKIMRH EEQVQRIAEN MHAQSSQAWR
TFAAYAERMP FGERLMMFLN AIFGYVGGLA GALRAPLLTT AESGLVILVG VLIGLNMAVI
SVVTEWASDL KQGYCSAGWW LNKKFCCWED MDPAGPGAGS GPKGMAALAA AAAANANTTS
VASAIQTMTR LTLRSESPVA PVETCNEWIE WAAWTVPAWF VYIGFSALLA FSCAYLVKQY
APYAAGSGIS EIKCVLSGFV IRGFLSAWTL VIKSLGLPLA IASGLSVGKE GPAVHVACCM
GYTASEVFHW LVPSHAKLRE LLTASSAAGV AVAFGSPVGG VLFALEEMTS HFPAQTMWRT
FLCALASTVA LSFMNPFRTG KLVLFQVEYN RDWHYFEIAF FLLLGAFGGL YGEYVARFNL
QVQRFRRKRL ANHGVAEAVI LAVLTAMVSY FNRFMRIDMT ESLEILFQQC DGASENDVLC
QSRMQWSMAT SLLLATILRF MFVVLSYGCK VPAGIFIPSM AVGATFGRMI GILVKAMQSA
FPSWSMFAAC NPHEPCITPG TYAMLGAAAG LAGVTRITVA VVVIMFELTG ALTYILPIML
VVGTAKLVAD LNGKGGISDR AIKFNGYPYL EQEEHIFGAE VGSLIQKQPD ALYADGMKLS
DIEKYVSEAT YRGFPVVSSR NDATVLGYVE RNHLRYAIDQ TSKLQSLTPE VVCKFYPKGT
EEYALTTAQM PKDLPETMRW GSGAFDEPDY ILEESMEVDS GPLDLGSWVD PTPLMVQPEL
DLEVVAEMFK SLGPRVILVC KNGQLQGLVT IKDLIRHLTE REKEEQQPTY VPANMQDSHM
DTNFMVGSGE LEETLELTWQ WMTSLTKRFK WWPNASHNVD NVPLTTVTTV HQDE
//
