ID A0A0M8MNH6_9BASI Unreviewed; 533 AA.
AC A0A0M8MNH6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
GN ORFNames=Malapachy_3205 {ECO:0000313|EMBL:KOS16056.1};
OS Malassezia pachydermatis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=77020 {ECO:0000313|EMBL:KOS16056.1, ECO:0000313|Proteomes:UP000037751};
RN [1] {ECO:0000313|EMBL:KOS16056.1, ECO:0000313|Proteomes:UP000037751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 1879 {ECO:0000313|EMBL:KOS16056.1,
RC ECO:0000313|Proteomes:UP000037751};
RA Triana S., Ohm R., Gonzalez A., DeCock H., Restrepo S., Celis A.;
RT "Draft Genome Sequence of Malassezia furfur CBS1878 and Malassezia
RT pachydermatis CBS1879.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a diacylglycerol + H2O = a fatty acid + a monoacylglycerol +
CC H(+); Xref=Rhea:RHEA:32731, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17408, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868;
CC Evidence={ECO:0000256|ARBA:ARBA00043665};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a monoacylglycerol + H2O = a fatty acid + glycerol + H(+);
CC Xref=Rhea:RHEA:15245, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17408, ChEBI:CHEBI:17754, ChEBI:CHEBI:28868;
CC Evidence={ECO:0000256|ARBA:ARBA00043831};
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS16056.1}.
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DR EMBL; LGAV01000001; KOS16056.1; -; Genomic_DNA.
DR RefSeq; XP_017993688.1; XM_018137682.1.
DR AlphaFoldDB; A0A0M8MNH6; -.
DR STRING; 77020.A0A0M8MNH6; -.
DR GeneID; 28729558; -.
DR VEuPathDB; FungiDB:Malapachy_3205; -.
DR OrthoDB; 5473102at2759; -.
DR Proteomes; UP000037751; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01672; TMPK; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR005645; FSH-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR Pfam; PF03959; FSH1; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:KOS16056.1};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000037751};
KW Transferase {ECO:0000313|EMBL:KOS16056.1}.
FT DOMAIN 95..247
FT /note="Serine hydrolase"
FT /evidence="ECO:0000259|Pfam:PF03959"
FT DOMAIN 317..494
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
SQ SEQUENCE 533 AA; 59750 MW; 6DC8614A7D033C80 CRC64;
MHEYKIVIPV PGSTEEAAAQ GHGIHGVLRV YGQPEEASLP ANGSCEGKPL AIFTHGLLSH
KNALFFRPMT GMVGMDSFRW DMVGEGESPG DWKAGDYPRS IEMLRHVVDY ITKRFGYHID
LMVGHSKGCV VTSAYVSQYC SLGAKHRGHR PPRRMILCSG RIRMENLRRK DAVFNPQFER
HGHAVINVKV RGVMKEYRIY PDDHESQCSF PTRQYVQQIP PHIRIFIAHG TLDEVVPVVD
AGDMVSVLTS HPYRQPGTVH LELIEGADHN YRGEYNDILL KKAQQWLESS ALALETSKPT
TAVPTPVGVR RGALIVVEGL DRSGKSTQVE RLVQRLQAQL VKFPDRTTSI GTMINSYLTQ
QSDVNDQSIH LLFSANRWEV ITSILNALRR GQNVVCDRYA FSGIAYSRAK GLDLEWCISP
DVGLPIPDLT LFLDVDEATA TKRAAYGEER YEKRAFQRLV REAFYNVETL VRYAGATWVR
IDAGASIDQV SEQIMSHVTR TSEHLPTNLM TLSLDVMRPA LTFVPDANEK ASL
//
