ID A0A0M8MSG6_9BASI Unreviewed; 492 AA.
AC A0A0M8MSG6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Trna guanosine-2-o-methyltransferase {ECO:0000313|EMBL:KOS15857.1};
GN ORFNames=Malapachy_3666 {ECO:0000313|EMBL:KOS15857.1};
OS Malassezia pachydermatis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=77020 {ECO:0000313|EMBL:KOS15857.1, ECO:0000313|Proteomes:UP000037751};
RN [1] {ECO:0000313|EMBL:KOS15857.1, ECO:0000313|Proteomes:UP000037751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 1879 {ECO:0000313|EMBL:KOS15857.1,
RC ECO:0000313|Proteomes:UP000037751};
RA Triana S., Ohm R., Gonzalez A., DeCock H., Restrepo S., Celis A.;
RT "Draft Genome Sequence of Malassezia furfur CBS1878 and Malassezia
RT pachydermatis CBS1879.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS15857.1}.
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DR EMBL; LGAV01000001; KOS15857.1; -; Genomic_DNA.
DR RefSeq; XP_017993489.1; XM_018138128.1.
DR AlphaFoldDB; A0A0M8MSG6; -.
DR STRING; 77020.A0A0M8MSG6; -.
DR GeneID; 28730004; -.
DR VEuPathDB; FungiDB:Malapachy_3666; -.
DR OrthoDB; 5488599at2759; -.
DR Proteomes; UP000037751; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KOS15857.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037751};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KOS15857.1};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 221..348
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
FT REGION 473..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 55665 MW; 7C6E89222F408CEE CRC64;
MTALREKDAP WGRVYVLHCA HSHTDFRIPE IVASAEYLGL RHELLPTPSR ECPDGLLGDV
SRPFMLCRLE DDEAARQMLR RCSCLRGIWE LWACADTYVD LHARNQARRA YEPWLAPQYT
WKALMQGFNV AMGSKRRIAL IESFSYMDFK GPTQMRGSDV TWGVLEEYRR PTDPQDVEAR
GHAELGDRDP RLVQLFLGRK IKDRTGAMPA RDLIDALDLK KRTYIGNTSM ESEMSVIMAT
MALAGPGQFI YDPFAGTGSM LYACSMLGAF TFGSDIDGRM LRGKDRQGPS GITRSAQQYG
LRGRVVDTAV FDMTQSPWRV PFRGEVGLFD AIVTDPPYGV RAGAKRQGRR NIEHQRDEPF
IMADGRAAHT LPDYIPPTKP YHLSELIADL LAYASALLRP GGRLVFWLPT MTEDDVETTI
PEHKHFVLVA HSLQDFGRWG RRLITMQKKD DAAQSTMPSS YDRMAVPRRM LANEKPDEFR
NRLFTPPPAT SS
//
