ID A0A0M8MTJ3_9BASI Unreviewed; 594 AA.
AC A0A0M8MTJ3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Bifunctional purine biosynthesis protein ade10 {ECO:0000313|EMBL:KOS14054.1};
GN ORFNames=Malapachy_4086 {ECO:0000313|EMBL:KOS14054.1};
OS Malassezia pachydermatis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=77020 {ECO:0000313|EMBL:KOS14054.1, ECO:0000313|Proteomes:UP000037751};
RN [1] {ECO:0000313|EMBL:KOS14054.1, ECO:0000313|Proteomes:UP000037751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 1879 {ECO:0000313|EMBL:KOS14054.1,
RC ECO:0000313|Proteomes:UP000037751};
RA Triana S., Ohm R., Gonzalez A., DeCock H., Restrepo S., Celis A.;
RT "Draft Genome Sequence of Malassezia furfur CBS1878 and Malassezia
RT pachydermatis CBS1879.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-
CC 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route):
CC step 1/1. {ECO:0000256|ARBA:ARBA00004954}.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP
CC from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step
CC 1/1. {ECO:0000256|ARBA:ARBA00004844}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the PurH family.
CC {ECO:0000256|ARBA:ARBA00007667}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS14054.1}.
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DR EMBL; LGAV01000004; KOS14054.1; -; Genomic_DNA.
DR RefSeq; XP_017991686.1; XM_018138541.1.
DR AlphaFoldDB; A0A0M8MTJ3; -.
DR STRING; 77020.A0A0M8MTJ3; -.
DR GeneID; 28730417; -.
DR VEuPathDB; FungiDB:Malapachy_4086; -.
DR OrthoDB; 275312at2759; -.
DR UniPathway; UPA00074; UER00133.
DR Proteomes; UP000037751; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01421; IMPCH; 1.
DR Gene3D; 1.10.287.440; -; 1.
DR Gene3D; 3.40.140.20; -; 2.
DR Gene3D; 3.40.50.1380; Methylglyoxal synthase-like domain; 1.
DR HAMAP; MF_00139; PurH; 1.
DR InterPro; IPR024051; AICAR_Tfase_dup_dom_sf.
DR InterPro; IPR024050; AICAR_Tfase_insert_dom_sf.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR011607; MGS-like_dom.
DR InterPro; IPR036914; MGS-like_dom_sf.
DR InterPro; IPR002695; PurH-like.
DR NCBIfam; TIGR00355; purH; 1.
DR PANTHER; PTHR11692:SF0; BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC; 1.
DR PANTHER; PTHR11692; BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH; 1.
DR Pfam; PF01808; AICARFT_IMPCHas; 1.
DR Pfam; PF02142; MGS; 1.
DR PIRSF; PIRSF000414; AICARFT_IMPCHas; 1.
DR SMART; SM00798; AICARFT_IMPCHas; 1.
DR SMART; SM00851; MGS; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR SUPFAM; SSF52335; Methylglyoxal synthase-like; 1.
DR PROSITE; PS51855; MGS; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000037751};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..147
FT /note="MGS-like"
FT /evidence="ECO:0000259|PROSITE:PS51855"
SQ SEQUENCE 594 AA; 64143 MW; 9B805D27E17D9DB5 CRC64;
MSQPTAILSV YDKTGLIELA QGLAAKGVRL LGSGGTARAV RNAGIEIGDV SDITKAPEML
QGRVKTLHPA VHGGILARTS LESDRSDLET QQIAPIDIVV CNLYPFEETV ARDPAPTIAE
AVEEVDIGGV TLIRAAAKNH DRVWVLCDPK DYSTFLSQYG EESDAAKQSR ERFALKGFTH
TAHYDTAISQ YFREKYASAP REPVQQMTLR YGANPHQKPA QAFVEEGALP FTALSGSPGY
INLLDGLNAW ALVKELSEAT QRAAAASFKH VSPAGAAVAV PLSEAEARAC FVADLGELSP
IATAYARARG ADRMSSFGDF IALSHVCDEQ TAKMISREVS DGVIAPGYEP AALELLRAKK
GGKYCVLRMD PSYEPATTES RQVYGVTLQQ RRNDLKITPA LFENIVSAAK DVPESATLDM
LVATIALKYT QSNSVCYALH GQVIGLGAGQ QSRIHCTRLA GGKADNWWLR QHQRVLDLPF
KKGTKRPEKS NAIDLFVEGT PLDGEERAQW ESVFETVPAP LSAEERAQHA AQLKDVVVAS
DAFFPFPDNV HRAARSGAKY IAAPGGSVMD DACVAAADAH HMVVARTNVR LFHH
//
