ID   A0A0M8NRW0_9EURO        Unreviewed;      1011 AA.
AC   A0A0M8NRW0;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   13-SEP-2023, entry version 22.
DE   RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=ACN38_g11749 {ECO:0000313|EMBL:KOS37458.1};
OS   Penicillium nordicum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=229535 {ECO:0000313|EMBL:KOS37458.1, ECO:0000313|Proteomes:UP000037696};
RN   [1] {ECO:0000313|EMBL:KOS37458.1, ECO:0000313|Proteomes:UP000037696}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DAOMC 185683 {ECO:0000313|EMBL:KOS37458.1,
RC   ECO:0000313|Proteomes:UP000037696};
RA   Nguyen H.D., Seifert K.A.;
RT   "Genome sequencing of Penicillium nordicum.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC       {ECO:0000256|ARBA:ARBA00009665}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOS37458.1}.
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DR   EMBL; LHQQ01000318; KOS37458.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M8NRW0; -.
DR   STRING; 229535.A0A0M8NRW0; -.
DR   OrthoDB; 7162at2759; -.
DR   Proteomes; UP000037696; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14475; SPX_SYG1_like; 1.
DR   InterPro; IPR004342; EXS_C.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR   PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR   Pfam; PF03124; EXS; 1.
DR   Pfam; PF03105; SPX; 1.
DR   PROSITE; PS51380; EXS; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037696};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        547..567
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        588..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        616..634
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        737..756
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        768..790
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        810..832
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          9..449
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   DOMAIN          699..893
FT                   /note="EXS"
FT                   /evidence="ECO:0000259|PROSITE:PS51380"
FT   REGION          41..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          887..927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          962..1011
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        977..991
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        992..1011
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1011 AA;  115631 MW;  EB50F246F3E80B93 CRC64;
     MIGSEPALPG IKPELEQELV PEWRAKYLDY KTGKKKVKAI TRALQKANRS PHVPSNRQPT
     STPQGRDAAS SALAPSNTDK ELHVGEHNSP STPQRGASNL PSTTRSTPVA KTERQPLRTP
     GSRFSENVGS YGSILATPPQ HHTAGSDIAS FELPDPALDP DGEYLPHEDT ANRSRHPRTP
     SPVMDRRSIA NMSPSHPIPE SLPAQSPQLD HQRTSYQSQI GDALAKVPSG HRTSQLLRRV
     FTAEGEPGGR WSQFDAGAGA GAEVDKRQDE FFEFLDSELN KIDAFYVMKE QEATEKLRVL
     RQQLHIMRDQ RIQEVLASKK TAKYDDSDTQ QRPNGFAKIK GGRIKDTLAG KNRFGKNTEA
     LAQMATPGMQ PQERDFIANR RDFMRRQDPQ SQEVPYRSAK RKLKHALQEF YRGVELLKGY
     AYLNRTAFRK INKKYDKAVN TRPPLRYMFE KVNKASFVQS DVIESLMVAV EDLYSRYFER
     GNRKIAASKL RHTINKSGDY SPNTFRSGLL LMGGTLFSIK ALVDARSNLR SAEIAEQVRT
     SYLLQIYGGY FLIVFHFLLF CLDCMIWTKS KINHSFVFEY DSRHTLEWRQ LLEIPSFFLF
     LMGLFMWLNF SWYNHMYIYW PVVLIGLTII IIFLPARVLH HRSRKWFAFS NWRLLLAGIY
     PVEFRDFFLG DMYCSQTYAM GNIELFFCLY ASYWDYPPKC NSSHSRLLGF FQCLPSVWRA
     FQCIRRYVDT KNAFPHLLNL GKYIFGVLYY ATLSMYRIDL QTRFQASFIT FALLNAVYTS
     VWDLIMDWSL GNPYAKNPML RELLAFRRVW VYYAAMLLDV VVRFNWIFYA VFIKNIQQSA
     LLSFLVAFSE VCRRGVWSIF RVENEHCTNV LLFRASRDVP LPYDVPSPAA PPLDGSAEDV
     QLQEQQHAST PFMSPGDIEH GTPSMSSLRA RHRRPSVGIG RVGTIVASAH AQDFERKRLP
     NFMSSASVGR DMAHDADDST DEDDEADLST DDDPESRPAS ERRDTMGRIV E
//