ID A0A0M8NXU1_9EURO Unreviewed; 1240 AA.
AC A0A0M8NXU1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Cell division control protein Cdc25 {ECO:0008006|Google:ProtNLM};
GN ORFNames=ACN38_g7609 {ECO:0000313|EMBL:KOS41486.1};
OS Penicillium nordicum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=229535 {ECO:0000313|EMBL:KOS41486.1, ECO:0000313|Proteomes:UP000037696};
RN [1] {ECO:0000313|EMBL:KOS41486.1, ECO:0000313|Proteomes:UP000037696}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOMC 185683 {ECO:0000313|EMBL:KOS41486.1,
RC ECO:0000313|Proteomes:UP000037696};
RA Nguyen H.D., Seifert K.A.;
RT "Genome sequencing of Penicillium nordicum.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS41486.1}.
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DR EMBL; LHQQ01000130; KOS41486.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8NXU1; -.
DR STRING; 229535.A0A0M8NXU1; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000037696; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037696};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1217..1235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..132
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 799..933
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 968..1204
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 147..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1240 AA; 139197 MW; C783A64529B4D91C CRC64;
MFEIRATDLA VDTTALAKSG SVATAFEYTD EQVTTPTALS RYRGRGNSVS RDYNHIKHSP
VEMASGYAVS PEPPALFVRA MYDYDADDHT SLSFRRGDII QVLNQLETGW WDGVIDDVRG
WFPSNYCTPL TDADDFSDQF VHAHHETDLS ADSGLEDEYG DGHDEDEVNS EGNSREPQPI
LPVEGIPAPK EQEEAAFWIP QATPDGRLFY FNTLTGYSTM ELPFENPTAT TEPGPRDRNN
FFVPDQTRPP PELMARGFER DEDEYDGSAS ETEGESLMLG SHDSISRRRQ SVMDGVSPAT
SMDSLYAPGS KDFKMPQPPS KNSQKLYSLG GSSTSTSVTE SFSRPSISSN PPQHFIDDGF
APPITWPLLV DNMRSAVEAY RQTLFNGERA EYVRKAEDIS DHLRMLLAAG SDTTDNHSGN
PSIISTNKAL YPYFRDMMSK FSKLVLSSHI AAADWPGADS ANKCLQEADG VMQGVYGYVE
VAQQQRGDAI HRIVPGFVSG SSSGGSWQNN GVSLNASGPT SFLVPDGGDS RAEPSVSLDT
AFLDSIDILR RSFVGSIRRL EELLIVNRKI VTVEEHGDMA DAISAAAIKV IEQFRPWISS
VESMNLAPLG TSFQNPQLVD FSLQKQRVYD AIGDFVLSCQ AVSAPLADEW AELRGNSLDD
RVNAVRGIAR QLENCVSQIG FSLSLLLEQI PTETASSLQR DTRQEAEDES YKNMHKRAES
KAKIATESIG IPSSYAPEKE GGTDKVRRNM DKAQRFFGQA PPTAITREPI REPVREPEET
PWFLKMAHEG EVFYDNKGDL PILKCGTLAG LVEHLTRHDK LDASFNNTFL LTYRSFTTAT
ELFELLVQRF NIQPPFGLNQ DDMQMWIDRK QKPIRFRVVN ILKSWFDHFW MEPNDEMHMD
LLRRVHTFTS DSIATTKTPG TPTLLAVIEQ RLRGQDTTVK RLVPTQSTAA PAPIIPKNMK
KLKFLDIDPT EFARQLTIIE SRLYSKIRPT ECLNKTWQKK VGPDEPEPSP NVKALILHSN
QLTNWVAEMI LAQGDVKKRV VVIKHFVNVA DKCRSLNNYS TLTSIISALG TAPIHRLGRT
WGQVSGRTSA ILEQMRRLMA STKNFGEYRE TLHLANPPCI PFFGVYLTDL TFIEDGIPSL
TPSELINFNK RAKTAEVIRD IQQYQNVPYL LQPVGELQDY ILSNLQGAGD VHDMYERSLE
IEPREREDEK IARQVCLFFF FFFFFFFFFF LFFSLKTITI
//
