ID A0A0M8P6G4_9EURO Unreviewed; 2273 AA.
AC A0A0M8P6G4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KOS42274.1};
GN ORFNames=ACN38_g6855 {ECO:0000313|EMBL:KOS42274.1};
OS Penicillium nordicum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=229535 {ECO:0000313|EMBL:KOS42274.1, ECO:0000313|Proteomes:UP000037696};
RN [1] {ECO:0000313|EMBL:KOS42274.1, ECO:0000313|Proteomes:UP000037696}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOMC 185683 {ECO:0000313|EMBL:KOS42274.1,
RC ECO:0000313|Proteomes:UP000037696};
RA Nguyen H.D., Seifert K.A.;
RT "Genome sequencing of Penicillium nordicum.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] =
CC ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate;
CC Xref=Rhea:RHEA:13501, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145,
CC ChEBI:CHEBI:456216; EC=6.3.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000861};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-
CC CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001455};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS42274.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LHQQ01000110; KOS42274.1; -; Genomic_DNA.
DR STRING; 229535.A0A0M8P6G4; -.
DR OrthoDB; 911at2759; -.
DR UniPathway; UPA00655; UER00711.
DR Proteomes; UP000037696; Unassembled WGS sequence.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF3; ACETYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000037696}.
FT DOMAIN 46..554
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 198..395
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 681..755
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1506..1848
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 1852..2167
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 2273 AA; 253452 MW; 06D45830B27E858A CRC64;
MGITNGNGAT IAKQDLPSHF IGGNALESAP PSAVKDFVTA HDGHSVITSV LIANNGIAAV
KEIRSVRKWA YETFGNERAI QFTVMATPED LTANADYIRM ADQYVEVPGG TNNNNYANVE
LIVDIAERMD VHAVWAGWGH ASENPRLPES LAASPKKIIF IGPPASAMRS LGDKISSTIV
AQHAGVPCIP WSGTGVDAVK LDEHGIVTVE DEVYKQGCTF SPEEGLAKAK EIGFPVMVKA
SEGGGGKGIR KVENEEEFHA LYNAAANEIP GSPIFIMKLA GNARHLEVQL LADQYGNNIS
LFGRDCSVQR RHQKIIEEAP VTIAKQPTFQ AMERAAVSLG RLVGYVSAGT VEYLYSHSDD
KFYFLELNPR LQVEHPTTEM VSGVNLPAAQ LQIAMGIPLH RVRDIRLLYG VDANASADID
FDFSNEESFQ TQRRPQPKGH TTACRITSED PGEGFKPSSG TMHELNFRSS SNVWGYFSVG
TAGGIHSFSD SQFGHIFAYG ENRSASRKHM VVALKELSIR GDFRTTVEYL IKLLETPAFE
DNTITTGWLD QLITNKLTAE RPDQTVAIIC GAVTKAHLAS EAGIEEYRHG LGKGQVPSKE
ILKTVFPVDF IYEGERYKFT ATRASLDSYH LFINGSKCSV GVRALADGGL LVLLSGRSHN
VYWKEEAAAT RLSVDGKTCL LEQENDPTQL RSPSPGKLVK FTVENGEHIR SGQSYAEVEV
MKMYMPLIAK EDGIVQLIKQ PGATLEAGDI LGILALDDPS RVKHAQPFTG QLPELGSPTV
LGNKPSQRFF LLHSILENIL RGFDNQVIMG TTLKDLVEVL RNPDLPYGEW NAQSSALHSR
IPQRLDAQLQ NVVDRAKTRK AEFPAKQLQK AIVRFIEENI GPADAEILKG TLLPLVQVIN
KYLDGLKSNE YNVFIGLLEQ YYDVEKLFST HNLRDEDVIL KLREENKDDI TSIVHTVLSH
SRIGSKNNLV LAILDMYRPN QPLLENVGTH FKPILKKLTE LEARSSAKVT LKAREVLIQC
AMPSLDERLS QMEHILRSSV VDSRYGETGW EHREPSLEVL KEVVDSKYTV FDVLPRFFVH
ADPWVTIASL EVYVRRAYRA YTLKGIEYHA STEQPFMSWD FTLGKLGHRE FGVLNSTQPS
APGTPVAEIN PFKRINSIGD MSLFVSDAAS DPVRKGVIIP VQYLEDAEES LSKALEVFPV
GGSNAKRPSE QGLIASLEGK RRPATKPVSD SELTGVCNIA IRDIEDMEDS EIVEQMKQLL
ADNKDELLAR RIRRVTFICG KQGVYPGYFT FRGPNYEEDL SIRHSEPALA FQLELGRLSK
FNIKPVFTEN RNIHVYEAMG KGPENDKAID KRYFIRAVVR PGRLRDDIPT AEYLISEADR
LMNDILDALE IIGNNNSDLN HIFINFSPVF NLQPVDVEQA LAGFLDRFGR RLWRLRVTGA
EIRILCTDPA TGMPYPLRVI ISNTYGFIIN VELYIERKSE KGEWIFQSIG GTAKLGSMHL
RPVATPYPTK EWLQPKRYKA HLMGTQYVYD FPELFRQAFQ NSWTKIAEKI PSLYEKRPPV
GECIDYSELV LDDTDNLVEV SREPGTNTHG MVGWIITART PEYPRGRRFI IVANDITFQI
GSFGPQEDKF FHKCTELARK LGIPRIYLSA NSGARIGVAD EIIPYFSVAW NNPEKPEAGF
KYLYLTPEVK KRFDASKKKE VITELINDEG EERHKITTVI GAKDGLGVEC LKGSGLIAGA
TSKAYEDIFT ITLVTCRSVG IGAYLVRLGQ RAIQVEGQPI ILTGAPAINK LLGREVYTSN
LQLGGTQIMY KNGVSHMTAT DDFEGVEKIV EWMSFVPDKK NAPIPIRPWS DNWDRDVAYF
PPPKQPYDVR YLIGGKEDVD GFLPGLFDKG SFEEALGGWA RTVVVGRARL GGIPMGVIAV
ETRSVENVTP ADPANPDSME MISTEAGGVW YPNSAYKTAQ ALRDFNNGEQ LPVMILANWR
GFSGGQRDMY NEVLKYGSYI VDALVKYEQP IFVYIPPHGE LRGGSWVVVD PTINPDQMEM
YADEESRGGV LEPEGMVNIK YRRDKQLDTM ARLDATYGEL RRSLADTSLT NEQLTEVKAK
MATREEQLLP VYMQIALQFA DLHDRAGRMQ AKNTIRKPLQ WVNSRRFFYW RLRRRLSEET
IVKRMVAASA PPAPGADAFG QSLRATHLRT LHAWTGLLDE ELEHDDHKVA TWYEENKKVV
QSKVESLRTD GVASEVAQLL IGNKEGGLRG VQQVLSMLPV EERENVLKYL GSA
//
