ID   A0A0M8PA33_9EURO        Unreviewed;       691 AA.
AC   A0A0M8PA33;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   13-SEP-2023, entry version 36.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KOS48258.1};
GN   ORFNames=ACN38_g835 {ECO:0000313|EMBL:KOS48258.1};
OS   Penicillium nordicum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=229535 {ECO:0000313|EMBL:KOS48258.1, ECO:0000313|Proteomes:UP000037696};
RN   [1] {ECO:0000313|EMBL:KOS48258.1, ECO:0000313|Proteomes:UP000037696}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DAOMC 185683 {ECO:0000313|EMBL:KOS48258.1,
RC   ECO:0000313|Proteomes:UP000037696};
RA   Nguyen H.D., Seifert K.A.;
RT   "Genome sequencing of Penicillium nordicum.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00006743}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOS48258.1}.
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DR   EMBL; LHQQ01000007; KOS48258.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M8PA33; -.
DR   STRING; 229535.A0A0M8PA33; -.
DR   OrthoDB; 1381745at2759; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000037696; Unassembled WGS sequence.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR004621; Fadh2_euk.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   NCBIfam; TIGR00677; fadh2_euk; 1.
DR   PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037696}.
FT   REGION          367..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   691 AA;  77145 MW;  24807C871EECB332 CRC64;
     MEKKITEKIA ALPPDANYFS LEFFPPKTRM GFANLSARLE RMAQALRPLF VTVTWGAGGS
     TAARSLELAE VCQRQLQLTT VLHLTCTNMS RKLVDMALDE AKALGIRNIL ALRGDPPRSE
     EYNMHGEDDS NKDFTFAVDL VRYIRQTHGD YFCVGVAAYP EGHPADIFQD VQDPARDIPY
     LVEKTLAGAD FIMTQLTYDI EAYQKFENAL RSHESGAFKT IPIIPGLMPI HSYKILTRVT
     KLSHVTIPPP IARRMEEFKH DDDAVKRAGV DIVSEIVGGM RDIPSPGPRG FHFYTLNLEK
     TVSFILEQCD LIPSYSDAGE LAIEDDPASI PLDFPGRALR RRRASSINSQ PHNRVIVDKL
     SVHESSQDSV HEALADSAGM PAPPPNRSTT LLISEGLGAL GREATWDDFP NGRWGDARSP
     AFGEIDGYGP SLHVTANSAR RLWGSPVDSK DMSTLFRRHV SGELHMVPWS EGGAEEDGDG
     LNAETELIRP ELLKLIDGRG WWTLASQPAV NGVHNDHPIF GWGPQREGFV FQKPFVEFFC
     SSNDYTNILK PMFAKHGHDK LTWFATNIKG DFESSLPIQP ADVELDDLGS NPESVNAVTW
     GVFRGKEIVT PTIIEEVSFR AWGEEAFRIW DEWRRIYPRG SPSETYLDTT KNDSWLVCVV
     GQQFGAGTKQ GSKEEEDEVK WMWRVLAGEE A
//