ID A0A0M8S2Y0_9ACTN Unreviewed; 666 AA.
AC A0A0M8S2Y0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=aminodeoxychorismate synthase {ECO:0000256|ARBA:ARBA00013139};
DE EC=2.6.1.85 {ECO:0000256|ARBA:ARBA00013139};
GN ORFNames=ADK51_31135 {ECO:0000313|EMBL:KOU16482.1};
OS Streptomyces sp. WM6368.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415554 {ECO:0000313|EMBL:KOU16482.1, ECO:0000313|Proteomes:UP000037718};
RN [1] {ECO:0000313|EMBL:KOU16482.1, ECO:0000313|Proteomes:UP000037718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6368 {ECO:0000313|EMBL:KOU16482.1,
RC ECO:0000313|Proteomes:UP000037718};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the anthranilate
CC synthase component I family. {ECO:0000256|ARBA:ARBA00005970}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU16482.1}.
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DR EMBL; LGDA01000289; KOU16482.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8S2Y0; -.
DR PATRIC; fig|1415554.3.peg.6560; -.
DR Proteomes; UP000037718; Unassembled WGS sequence.
DR GO; GO:0046820; F:4-amino-4-deoxychorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005802; ADC_synth_comp_1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR006221; TrpG/PapA_dom.
DR NCBIfam; TIGR00553; pabB; 1.
DR NCBIfam; TIGR00566; trpG_papA; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF18; AMINODEOXYCHORISMATE SYNTHASE; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR Pfam; PF00117; GATase; 1.
DR PRINTS; PR00097; ANTSNTHASEII.
DR PRINTS; PR00099; CPSGATASE.
DR PRINTS; PR00096; GATASE.
DR SUPFAM; SSF56322; ADC synthase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..187
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT DOMAIN 210..341
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 386..640
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT ACT_SITE 82
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 666 AA; 72537 MW; F6AA21BEE1FCA99A CRC64;
MRILLVDNYD SYTWNLFQLI WKVAGVPPVV VRNDEATADE LLRQDFTHVV ISPGPGTAAR
DEDFGLCRDL LEQATVPVLG VCLGHQGLAL AFGGDVRHAP EIVHGQTSAI THTGTGVFAG
VPQGFRAVRY HSLTVTEPLP ADLVATAWSE GGLLMGLQHR ERPLYGVQFH PESVDSEYGE
EIIANFLGVT PTLRWSELDV ELDTEGLFLR AFAESPYSFW LDSSRTAYGM GRYSYLGACA
GDGLEVLRAY AGAGIVERET HEAMERLSGT VFEHLRAGLA TTPVAAGASP VPFAGGYLGY
LGYGIKGSVG IGRPGSGERP DAELLRVDRF VAYDHEAGRR YLITVGLSAE EHDAWCEEVR
VLARRPLVPR PRRETAPAVL EPGVDRETYL EHFDTVQQWL RDGDSYEACY TYQISGTSEA
DPLDTYLRLR ATNPAPYAAY VRLGERSLLS SSPERFITVA GNGEVEAKPI KGTAPRHADP
VADEAARAAL ETDRKIRSEN LMIADLLRND LGQVCDTGTV YVPKLMAAES YATVHQLVTT
VRGRLRADRG AVDCVQALFP GGSMTGAPKK RTVELLDELE PQERGVYSGS LGFFGFDGAA
DQSIVIRTIV WEGNRVRIGV GGALIVLSDG EEEFQETRLK ARALLRVLGV DELHEATSGT
AARYQG
//
