ID A0A0M8S6X6_9ACTN Unreviewed; 395 AA.
AC A0A0M8S6X6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=2-isopropylmalate synthase {ECO:0000256|ARBA:ARBA00012973};
DE EC=2.3.3.13 {ECO:0000256|ARBA:ARBA00012973};
GN ORFNames=ADK51_21355 {ECO:0000313|EMBL:KOU21830.1};
OS Streptomyces sp. WM6368.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415554 {ECO:0000313|EMBL:KOU21830.1, ECO:0000313|Proteomes:UP000037718};
RN [1] {ECO:0000313|EMBL:KOU21830.1, ECO:0000313|Proteomes:UP000037718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6368 {ECO:0000313|EMBL:KOU21830.1,
RC ECO:0000313|Proteomes:UP000037718};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine
CC from 3-methyl-2-oxobutanoate: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004689}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU21830.1}.
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DR EMBL; LGDA01000255; KOU21830.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8S6X6; -.
DR PATRIC; fig|1415554.3.peg.4495; -.
DR Proteomes; UP000037718; Unassembled WGS sequence.
DR GO; GO:0046912; F:acyltransferase activity, acyl groups converted into alkyl on transfer; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR10277:SF9; 2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR10277; HOMOCITRATE SYNTHASE-RELATED; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00816; AIPM_HOMOCIT_SYNTH_2; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Manganese {ECO:0000256|ARBA:ARBA00023211}.
FT DOMAIN 1..264
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 395 AA; 41363 MW; F846FDB1554A402A CRC64;
MWEESARDGA QAKTLMTPGF RVELARATGR VFGQDGPRHV VFAAGFPAVC GQEYEAVRRV
AVEAEGAVSV AAVCRGARRD LEQAMASVRG SRHARVMVVV PASEAMAQVM VHRPAPEALQ
GGVDLVKRAR DLDEEVAVDV CLADASRADH ALMAHYAQAM TGAGAGLIVL ADTVGAQLPA
GCREMFARVG AEAGAEVVLA SHLHNDLGLG LANTLQALAA GVRVVSSSWL GIAERAGMVA
TEQLLFLLAR HTDDLLGADA APWWTPPDLT GLPAIARKVA DETGVPLTVT TPVVGTGVAT
ISTGTPFVHP QLFQPYDPQQ VLGIPPQVLL THLASARVVT AVAARLGHAL DRDQARAAMA
WAKNRAYRTG RAVIDDDSFA DYLDGLTHPA AGGAR
//
