ID A0A0M8SFT6_9ACTN Unreviewed; 371 AA.
AC A0A0M8SFT6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Adenosylhomocysteinase {ECO:0000313|EMBL:KOU33433.1};
GN ORFNames=ADK51_07410 {ECO:0000313|EMBL:KOU33433.1};
OS Streptomyces sp. WM6368.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415554 {ECO:0000313|EMBL:KOU33433.1, ECO:0000313|Proteomes:UP000037718};
RN [1] {ECO:0000313|EMBL:KOU33433.1, ECO:0000313|Proteomes:UP000037718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6368 {ECO:0000313|EMBL:KOU33433.1,
RC ECO:0000313|Proteomes:UP000037718};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC {ECO:0000256|ARBA:ARBA00007122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU33433.1}.
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DR EMBL; LGDA01000049; KOU33433.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8SFT6; -.
DR PATRIC; fig|1415554.3.peg.1553; -.
DR Proteomes; UP000037718; Unassembled WGS sequence.
DR Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR InterPro; IPR000043; Adenosylhomocysteinase-like.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR PANTHER; PTHR23420:SF0; ADENOSYLHOMOCYSTEINASE; 1.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR SMART; SM00997; AdoHcyase_NAD; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
FT DOMAIN 157..319
FT /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT /evidence="ECO:0000259|SMART:SM00997"
SQ SEQUENCE 371 AA; 39686 MW; 6E6AA551F87E8F78 CRC64;
MRRLGSYFDD IVAQFPVEQP TASLLVTHLL PERPAFVRAV ARMSDLRAVL PKPKSISPDA
LAAVLRSTRC DPLSREAFGD PDAATAYLEE LAAGMPVVLL DIGGYFAPAL SEVCRKFSGR
ILGVVEDTEN GHQRYAEIDK LPCPVVSVAR SPLEDPEDFL VGQSVVFSTE ALLRTRGAIM
VGRRAAVIGF GKLGSSIARL LHAKGVPVTV YDIDPVRGTQ ALSQGFPVAA SLEAALERAD
VTICATGAKA LGHQDLALLK DGSFVASVTS AEDELDLERL PQTHTLTPVG EHITRCTSGD
RHFYLCNEGN AVNFLHGASV GPFIFLVQAE ILAGLSALSR GDLAPGLHEM PARDRAAIAA
TWLTHFNDRT S
//
