ID   A0A0M8SLX7_9ACTN        Unreviewed;      1038 AA.
AC   A0A0M8SLX7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN   ORFNames=ADK54_27980 {ECO:0000313|EMBL:KOU38325.1};
OS   Streptomyces sp. WM6378.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1415557 {ECO:0000313|EMBL:KOU38325.1, ECO:0000313|Proteomes:UP000037774};
RN   [1] {ECO:0000313|Proteomes:UP000037774}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM6378 {ECO:0000313|Proteomes:UP000037774};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOU38325.1}.
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DR   EMBL; LGDD01000306; KOU38325.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M8SLX7; -.
DR   PATRIC; fig|1415557.3.peg.6155; -.
DR   OrthoDB; 2472181at2; -.
DR   Proteomes; UP000037774; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          950..1025
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1038 AA;  112048 MW;  4A6C7CA3167DD5A6 CRC64;
     MSAAPAESDP EPPSAPALRT RPHPASPRPA SAAQSGIWFN ERLDDCLTVH HLPFSVRFEG
     DLDVAALRRA VAATVRRHEA LTSAVEDRAG APFLVPAARL PELVVERHGP GAVRRHVVAP
     FDLARGPLCR LVLLSAGPRE HRLLVVAHHL VFDGQSMGLL LADLAAFYRA EATGADAGVP
     ELLPAEPPGA EEDRIAADLP LAQAYWACHP LADDELMLPG LDRPAHGVTE GESVEFRFPD
     ELREGLGPVA RRIGVTRFEL IVASLHALLF RYGNRTPVTA IDLGTRTPEQ QDRIGVYVNE
     LPFSSAPEAD ATFEEFARAV RAGLRELYPV RDVPLGRVGV GVKPGVALAQ VSMSYRRPEA
     VPHFRGLTAR ADWSPSSHTA RNALRIEVAD APGELSVLLQ CPKRDAWREA PRSIARHWLT
     LLTRVVADPD TALTHLPLLD ADERERLLVE WNDTAAEQPG KTLPELFAEQ VTRTPDAVAV
     VHADRRLSYA ELDAAAERLA HRLRGRGIGP GDRVTVRAKR SERLVVALLG VLKSGAAYIP
     LDPEYPAQRL EFIAADSKAA LELGDADLVA CADTAISDAV SNTAPVNAGR RPRQAAPADL
     AYVIYTSGST GRPKGVQIEH RSLTNLLLSL RDLLDARPAD RWLALTSVSF DISGLELFLP
     LVTGATVVVA GQSQTRDGGA LGELVARHGI THIQATPTGW AMLLDAGFDD TTVTALTGGE
     ALPPALARRL RPMVGRLVNV YGPTETTIWS TADEVTEGEV AREPDRVAIG RPLANTRTYV
     LDAHLSPVPV GVAGDLYIAG TGLARGYLGR PDLDRERFLP DPFGPPGSRI YRTGDRARYR
     DDGRLEFLGR NDDQIKLRGY RIELGEIESR LLAVPGVDRA AAAVRDGRLV AYHVGGAEPG
     AVRRALAAEL AAYMVPEVLV ALDALPLTPN GKLDRRALPA PPDVPAPAAA VGDTPLEAVR
     EVWCEVLRLP DVGDTEDLFD LGGHSITMTQ ISARLLDRLG VDVPLDAYFE DPTVRGIAVV
     VAELTRQNWS PVQKMNQR
//