ID A0A0M8SN61_9ACTN Unreviewed; 2673 AA.
AC A0A0M8SN61;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
DE Flags: Fragment;
GN ORFNames=ADK51_04240 {ECO:0000313|EMBL:KOU36268.1};
OS Streptomyces sp. WM6368.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415554 {ECO:0000313|EMBL:KOU36268.1, ECO:0000313|Proteomes:UP000037718};
RN [1] {ECO:0000313|EMBL:KOU36268.1, ECO:0000313|Proteomes:UP000037718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6368 {ECO:0000313|EMBL:KOU36268.1,
RC ECO:0000313|Proteomes:UP000037718};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU36268.1}.
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DR EMBL; LGDA01000012; KOU36268.1; -; Genomic_DNA.
DR PATRIC; fig|1415554.3.peg.880; -.
DR Proteomes; UP000037718; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd12116; A_NRPS_Ta1_like; 1.
DR CDD; cd19540; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 976..1051
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2029..2104
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT NON_TER 2673
FT /evidence="ECO:0000313|EMBL:KOU36268.1"
SQ SEQUENCE 2673 AA; 284497 MW; DA5B6E3ADB2CD2F5 CRC64;
MTERPSQRLP LTGAQTGVWY GQRLDPDSPV YNVGQYVEID GPLDAGLFVA ALRRTVAESE
ALTARFAEGA DGEPYQVAWS GPAAGPLVAV LDHTEQDDPY GTALSLMRAD MARPVDPVRD
SLYVFTLHKV GPHRTLWYQR AHHIVLDAFG FSLLSRRTAE VYTALAGGQE PTPTPFGGLE
VILAEEHAYR ASPRCTEDRA YWLERLADHP EPEPLSGARY PAAHAFLRDG ATLTARETAG
LLAIARAAKA SWADVMTAAF AAYLHRATGS RDVLLSLPAM ARLGSAALKV PSMVVNVLPL
RVAVRPQTPL AELVAAVAAD IRDLRRHQRY RAEDIRRDLG LSGREQGLLG PMVNIKAFDN
SLDFAGAAGS VHNVAAGPVD DLTLGVYHDT TEGRIRFELD ANPQAYDAGT LAAHRAEFAH
FLREAAAAGP QAPVGRPDLL GPAARDAMLL DRNATDRAVP AGTVVDAFEQ AARLHPEVPA
VIAGADTLDY AALEERANRL ARLLIGRGAG PERVIGLALP RTADLVVALL AVLKAGGAYL
PLDLDYPADR LEFMVEDARP LCVLTTLDCA AAAPVVDGVE TVVLDAPDTL TELADAATGA
PADADRTAPL TGDHPAYVIY TSGSTGRPKG VVVPHSALAN FLRMQAHELE LAAGQRLVAV
TTISFDIAAL EIHTPLISGA TVVLADRDTV RDPAALAALV DAHRPSVMQA TPSLWHALLE
DGRPDSLEDT RVLVGGEALP AALAERLART ARTVTNVYGP TEVTVWATSS RLDPGHTGVP
DIGVPFWNTR AHVLDGALRP VGAGRPGELY LAGDQLARGY LGRPALTAER FVADPYGPAG
SRMYRTGDLV RRRADGRIDF LGRVDDQVKL RGFRIELGEI ESALTAGEGV DRAVALVRED
LPGFPHLVGY VTPAAQRPAP DAAGLRRAVA ERLPEYMVPS AVVVLDAFPL TANGKIDRRS
LPAPDLAALA GTGARAPRGA REEILCGVFA DVLGLESVGP DDDFFTLGGH SLLAARVIAR
VRTALGTECG IRDVFEARTV AALDALLAGR TAAARPAPVA GPRPDPLPLS YAQQRLWFVH
QVEGASATYN IPFVVRFDTA LDAEALDAAL RDVAGRHEVL RTVFGEQDGE PYQRVLDVAE
AGVRLRVHDV GADGSEAAVR AALGHLFDLS GEAPLRVTLV RDEARGEHAL VVLLHHIASD
EWSMGPFLRD LERAYAARCA GQDPDLGVPA VQYADFALWQ RELLGGTRSD GSPAATQAAY
WRSALAELPP EAGLPADRPR PAVADPAGAM VFKAVPRELA SAVRSLARES GTSVFMVVHA
AVAALLHRLG AGEDIVLGSP VAGRTDSALD ELVGFFVNTV VLRTDLSGDP SFTELLERVR
TADLAALDHA DLPFDSVVEE VNPQRSLARH PLFQTMVSHS TVTQDVANLF GYPARVDRVD
PGVTKFDLDI TFSDAAHGED LDLEVFYATA LFDRATVETF VQRLLRALAA AVAAPADPVS
WWELRDAAER ARLARWNDTD RPVEPGAVTE VFAARAAAAP DAVAVVAGEE RLTFAALEDR
AGRLAALLAA RGVGPDAVVA LAVPRSADTV VATLAVLKAG GAYLPLDLDH PAERIAFMLG
DAAPVCAVTT RAVADRLPGV DLVVLDDPAT VEELAAAVPG ADAPVDPEHA AYVIYTSGST
GRPKGVVLRH AGLTRLFRDH ERELYLPNAE RLGRRVRALH TASFSFDSSW EQLLWLVAGH
ELHVLDEYGR RDADAVVAYA RAERIDALDV TPSYGRQLVD AGLLTGAWRP PLFLLGGEAV
PPALWEELRA VPGVEVVNYY GPTEFTVDAL VARVSDSASP VVGRPLDNTR AHVLDGRLRP
VPVGVPGELY LAGEQGARGY LGRFALTAER FVADPFGSPG ARMYRTGDLV RHRADGLLEF
LGRVDDQVKI RGFRVEPAEV EAELAALDGV ASAAVVVRED TPGLPRLIGY VTGPADPVRL
RAELTGRLPE HLVPAAVMVL PVLPTNVNGK LDRAALPVPV AAAGAAGRAP RGAVEERIAE
VFSQVLGLPR VGVDEDFFRL GGHSLLATRV VARIRAALGA ECTVRDVFEL RTVAALAERL
AGRRAVARPA LVAAPRPERL PLSYAQARLW FLHRMDGPTA TYNIPLALRL RGELDAVALE
AAVRRVTARH EALRTVFAED AEGPYQRVLE PSEVVVPFVV ADVEPADLGR SLDAAAGHAF
DLEAETPLRV TVLRTAADDQ VLLLLLHHIA GDEWSAGPLL ADLAAAYAAR CAGGALETAP
LLVQYADYAL WQRELLGDPV VPGSVAHEQA GFWREALAGL PQELELPVDR PRPVRPTHEG
RTVTAALPQE LVAALEALAG DRGHTMYTVV TAAVAALLHR LGAGEDVPLG SPVSGRGEEA
LDPLVGFFVN TLVVRADLAG DPSFGELLRR TAAFGAAALA HADLPFDAVV EAVNPERSLS
RHPLFQTMVA YEDGGAEPLR ALGPLRAEEF PVTAGDAKFD LEILFRRTPG AGGSPAAMTC
GVRYATDLFD AETVRSLLAR LVRLLGAAAA APEVPLAELE LLDPAERAQV LEGWNDTVRP
VAPQTLDSLA AAGARRDPLA TALVFEGGEL SRGEFEERVN RLARLLIGCG VGPESVVAVA
LPRSFDLVVA LHAVVRAGGA YLPLDLGLPT ERL
//
