ID A0A0M8SQ31_9ACTN Unreviewed; 305 AA.
AC A0A0M8SQ31;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dihydrodipicolinate synthase {ECO:0000313|EMBL:KOU38519.1};
GN ORFNames=ADK55_34340 {ECO:0000313|EMBL:KOU38519.1};
OS Streptomyces sp. WM4235.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415551 {ECO:0000313|EMBL:KOU38519.1, ECO:0000313|Proteomes:UP000037699};
RN [1] {ECO:0000313|EMBL:KOU38519.1, ECO:0000313|Proteomes:UP000037699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM4235 {ECO:0000313|EMBL:KOU38519.1,
RC ECO:0000313|Proteomes:UP000037699};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU38519.1}.
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DR EMBL; LGDE01000469; KOU38519.1; -; Genomic_DNA.
DR RefSeq; WP_053684655.1; NZ_LGDE01000469.1.
DR AlphaFoldDB; A0A0M8SQ31; -.
DR PATRIC; fig|1415551.3.peg.7489; -.
DR OrthoDB; 9778880at2; -.
DR Proteomes; UP000037699; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000037699}.
FT ACT_SITE 145
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 173
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 214
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 305 AA; 32365 MW; BBDE534CB7121C10 CRC64;
MTHAHTPAPA RTRPWHGIMV ATALPLRDDL TVDHDAYAEH VAWLIANGCD GVVPNGSLGE
YQTLTDEERA RVVRTAVEAA GDGERVMPGV AAYGSAEARR WADQAAEAGA GSVLLLPPNA
FRADERTVRE HYAQVARAGL PVVAYNNPID TKVDLTPALL ARLHADGSIV AVKEFSGDVR
RAYEIAELAP GLDLLVGADD VLLELALAGA VGWIAGYPNA LPRSCATLYR AAVAGDLDTA
LPLYKSLHSL LRWDSKTEFV QAIKLSMDLA GRPGGATRPP RFPLTGETEA AVRAATEKAL
AEGLN
//
