ID A0A0M8TSU1_9ACTN Unreviewed; 1643 AA.
AC A0A0M8TSU1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=NAD-glutamate dehydrogenase {ECO:0000313|EMBL:KOU70764.1};
GN ORFNames=ADK57_11825 {ECO:0000313|EMBL:KOU70764.1};
OS Streptomyces sp. MMG1533.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415546 {ECO:0000313|EMBL:KOU70764.1, ECO:0000313|Proteomes:UP000037741};
RN [1] {ECO:0000313|Proteomes:UP000037741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMG1533 {ECO:0000313|Proteomes:UP000037741};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU70764.1}.
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DR EMBL; LGDG01000086; KOU70764.1; -; Genomic_DNA.
DR RefSeq; WP_053749364.1; NZ_LGDG01000086.1.
DR STRING; 1415546.ADK57_11825; -.
DR PATRIC; fig|1415546.3.peg.2580; -.
DR OrthoDB; 9758052at2; -.
DR Proteomes; UP000037741; Unassembled WGS sequence.
DR GO; GO:0004352; F:glutamate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0019551; P:glutamate catabolic process to 2-oxoglutarate; IEA:InterPro.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR048381; GDH_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028971; NAD-GDH_cat.
DR InterPro; IPR049062; NAD_Glu_DH_ACT2.
DR InterPro; IPR049064; NAD_Glu_DH_ACT3.
DR InterPro; IPR007780; NAD_Glu_DH_bac.
DR InterPro; IPR049059; NAD_Glu_DH_HM1.
DR InterPro; IPR049058; NAD_Glu_DH_HM2.
DR InterPro; IPR049056; NAD_Glu_DH_HM3.
DR InterPro; IPR024727; NAD_Glu_DH_N_ACT1.
DR PANTHER; PTHR43403; NAD-SPECIFIC GLUTAMATE DEHYDROGENASE; 1.
DR PANTHER; PTHR43403:SF1; NAD-SPECIFIC GLUTAMATE DEHYDROGENASE; 1.
DR Pfam; PF05088; Bac_GDH_CD; 1.
DR Pfam; PF21075; GDH_ACT1; 1.
DR Pfam; PF21076; GDH_ACT2; 1.
DR Pfam; PF21077; GDH_ACT3; 1.
DR Pfam; PF21074; GDH_C; 1.
DR Pfam; PF21073; GDH_HM1; 1.
DR Pfam; PF21079; GDH_HM2; 1.
DR Pfam; PF21078; GDH_HM3; 1.
DR PIRSF; PIRSF036761; GDH_Mll4104; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000037741}.
FT DOMAIN 47..193
FT /note="NAD-glutamate dehydrogenase N-terminal ACT1"
FT /evidence="ECO:0000259|Pfam:PF21075"
FT DOMAIN 428..520
FT /note="NAD-glutamate dehydrogenase ACT2"
FT /evidence="ECO:0000259|Pfam:PF21076"
FT DOMAIN 578..647
FT /note="NAD-glutamate dehydrogenase ACT3"
FT /evidence="ECO:0000259|Pfam:PF21077"
FT DOMAIN 757..1254
FT /note="NAD-glutamate dehydrogenase catalytic"
FT /evidence="ECO:0000259|Pfam:PF05088"
FT DOMAIN 1300..1636
FT /note="NAD-specific glutamate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21074"
FT REGION 17..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1643 AA; 183371 MW; 4D077C2C7B66C635 CRC64;
MQTKLDEAKA ELLERAARVA ENSPVGGHLP TGTTDESTPD RDTVLAFLQR YYLHTAPEDL
ADRDPVDIFG AALSHYRLAE NRPQGTANVR VHTPTVEGNG WTCSHSVVEV VTDDMPFLVD
SVTNELTRQG RGIHVVIHPQ VIVRRDVTGR LIEVVTAPVA GELPHDAHIE SWIHVEIDRE
TDRGDLKQIN SDLLRVLSDV REAVEDWEKM RDSALRMADE LPKEPVASDL REQDIEEARE
LLRWLSADHF TFLGYREYQL REDDSLVAVP GTGLGILRSD PHHAGGDSHP VSPSFERLPA
DARAKAREHK LLVLTKANSR ATVHRPSYLD YIGVKKFDAD GNVVGERRFL GLFSSAAYTE
SVRRVPVIRR KVEEVLERAG FSPNSHDGRD LLQILETYPR DELFQTPPDE LQSIVTSVLY
LQERRRLRLY LRQDEYGRYY SALVYLPRDR YTTGVRLRII DILKEELGGT SVDFTAWNTE
SILSRLHFVV RVPQGTELPQ LSDADKDRIE ARLVEAARSW ADGFGEALNA EFGEERAAEL
VRRYGNAIPE GYKADHNPRS AVADLAQLEK LTEEKGFSLS LYEPVGAAPE ERRFKIYRKG
ESITLSAVLP VLNRLGVEVM DERPYELRCS DRSVAWIYDF GLRMPRPKSG SGDYLGDDGR
ERFQEAFAAT WTGRAENDGF NALVLSAGLN WRQAMVLRAY AKYLRQAGST FSQDYMEDTL
RHNVHTTRLL VSLFEARMSP DRQRAGHELV DALLEELDAA LDQVASLDED RILRSFLTVI
KATLRTNFFQ EAAGGKPHDY VSMKFDPQAI PDLPAPRPAF EIWVYSPQVE GVHLRFGKVA
RGGLRWSDRK EDFRTEILGL VKAQMVKNTV IVPVGAKGGF VAKQLPDPAV DRDAWLAEGI
RSYKTFISAL LDITDNMVAG EVVPPADVVR HDGDDTYLVV AADKGTATFS DIANGVAETY
NFWLGDAFAS GGSAGYDHKG MGITARGAWE SVKRHFRELD VNTQAEDFTV VGIGDMSGDV
FGNGMLLSEH IRLVAAFDHR HIFIDPKPDA ATSYAERRRV FELPRSSWAD YDTALISTGG
GVFPRTAKAI PVNAHIREAL GIEDKVSKMT PADLMKAILK APVDLLWNGG IGTYVKASTE
THADVGDKAN DPIRVDGADL RVRVVGEGGN LGLTQLGRIE FALHGGKINT DAIDNSAGVD
TSDHEVNIKI LLNGLVADGD MTIKQRNKLL AEMTDEVGSL VLRNNYAQNT AIANALAQSK
DMLHAQQRYL RHLVREGLLD RALEFLPTDR QIRERLGAAQ GLTGPETAVL LAYTKITVAE
ELLHTSLPDD PYLRGLLQAY FPSALREKFG ERIDGHPLHR EITTTVLVND TVNTGGTTYL
HRLREETGAS LEEIVRAQTA ARAIFRSGVV WDAVEALDNK VEAAVQTRIR LHSRRLVERG
TRWLLNNRPQ PLQLAETVDF FGDRVEQVWV QLPKLLRGAD LEWYQKIYDE LTGAGVPDEV
ATRVAGFSSA FPTLDIVSVA DRMGRDPMDV AEVYYDLGDR LHITQLMDRI IELPRADRWQ
SMARASIRED LYAAHAALTA DVLAVGNGTS TPEQRFKAWQ EKNAPILSRA RTTLDEIQGS
ETFDLANLSV AMRTMRTLLR THS
//
