ID A0A0M8V3U1_9ACTN Unreviewed; 736 AA.
AC A0A0M8V3U1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KOV57610.1};
GN ORFNames=ADL01_40130 {ECO:0000313|EMBL:KOV57610.1};
OS Streptomyces sp. NRRL WC-3618.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519490 {ECO:0000313|EMBL:KOV57610.1, ECO:0000313|Proteomes:UP000037738};
RN [1] {ECO:0000313|EMBL:KOV57610.1, ECO:0000313|Proteomes:UP000037738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL WC-3618 {ECO:0000313|EMBL:KOV57610.1,
RC ECO:0000313|Proteomes:UP000037738};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV57610.1}.
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DR EMBL; LGDW01000492; KOV57610.1; -; Genomic_DNA.
DR RefSeq; WP_053747007.1; NZ_LGDW01000492.1.
DR AlphaFoldDB; A0A0M8V3U1; -.
DR PATRIC; fig|1519490.3.peg.8731; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000037738; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000037738}.
FT DOMAIN 323..500
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 503..603
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 736 AA; 78912 MW; 333135265B78EA9A CRC64;
MTQSTTIRWE QDRTGLVTLV LDDPDQSANT MNQAFRDSLA VVTDRLEAEK ETIRGVIITS
AKKTFFAGGD LRDLIRVTPD TAQELLDGGL AIKRDLRRIE TLGKPVVAAL NGAALGGGYE
IALACHHRVA LDAPGSKIGC PEVTLGLLPG GGGVVRTVRM LGIADALLKV LLQGTQYSPQ
RALQNGLVDE VAATQDELMA KARAFIDANP VSQQPWDKPG YRIPGGTPAN PRFAANLPAF
PANLRKQTNG APYPAPRSIL AAAVEGAQVD FETAQVIEAR YFVELAAGQT SKNMIQAFFF
DLQAVNSGAN RPKGIEPRPV RRVAVLGAGM MGAGIAYSCA RAGIEVVLKD VSAEAAARGK
NYSEKLCAKA VSRGRSTQEK ADELLARITP TADPQDVAGC DAVIEAVFED PALKHKVFQE
IQHLVEPDAL LCSNTSTLPI TALAEGVERQ ADFVGLHFFS PVDKMPLVEI IKGERTGQEA
LARAFDLVRQ IRKTPIVVND SRGFFTSRVI GHFINEGVAM VGEGIEPASV EQAAAQAGYP
AKVLSLMDEL TLTLPRRIRA ESKRAVEEAG GTWVTHPAEA VIDRMVDEFG RTGRSGGGGF
YEYGQDGRRT RLWPGLREHF GREGAASEEG AEGAEGVRIP FKDMQERMLF SEALDTVRLL
EEGVLTSVAD ANIGSIFGIG FPGWTGGVLQ YINGYEGGLP GFVARSRELA QRYGERFAPP
ALLVEKAAKG EGFVDG
//
