ID A0A0M8V8A1_9ACTN Unreviewed; 678 AA.
AC A0A0M8V8A1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:KOV58177.1};
DE EC=6.2.1.16 {ECO:0000313|EMBL:KOV58177.1};
GN ORFNames=ADK64_37485 {ECO:0000313|EMBL:KOV58177.1};
OS Streptomyces sp. MMG1121.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415544 {ECO:0000313|EMBL:KOV58177.1, ECO:0000313|Proteomes:UP000037687};
RN [1] {ECO:0000313|Proteomes:UP000037687}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMG1121 {ECO:0000313|Proteomes:UP000037687};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV58177.1}.
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DR EMBL; LGDV01000238; KOV58177.1; -; Genomic_DNA.
DR RefSeq; WP_053666500.1; NZ_LGDV01000238.1.
DR AlphaFoldDB; A0A0M8V8A1; -.
DR STRING; 1415544.ADK64_37485; -.
DR PATRIC; fig|1415544.3.peg.8138; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000037687; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KOV58177.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000037687}.
FT DOMAIN 44..100
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 105..479
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 545..620
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 678 AA; 73258 MW; D8BCFB48CC3A0972 CRC64;
MTTPHPEPFL TSDPKTAAGS RIADFARWAA RYQGAEGVQD PTDYQALHRW SVTDLEGFWA
AVWEYFAVDS VTEYERVLAD DTMPGARWFP GTTLNYAHHA LRNLQPDAPA INALDETGTG
YEITGRQLRA QVASVAATLR DLGVGQGDRV VGYLPNTPHA IIAFLATASL GAVWSVCGQD
YAPKAAADRF AQLRPTVLIT ADGYLFNGAT HDRRAASLEL AGALPTLKAT VLVKHLGLAW
PQARYAGLTV PWEDAATRTE YLTFAEVPFD HPLWIVFSSG TTGLPKGIVH GHGGVLLEHL
KILGLHCDLG LGDRLLWYTT THWMMWNLVV STLLTGATTC TYDGSPAPVG RPDILWELAA
RHRVTVFGTS PQYLLAMAKL GVEPSGYDLS AIRVIGSTGS TLPASAYSWV RDRVGTNIQL
ASTSGGTDIV SGFAGSAPTT PIWAGELSAP NLGVALAAYD AAGRPVVDQV GELVVTRPMP
SMPLYFWNDP DGSRFRDAYF AAYPGVWRHG DWITLTSHGS LIVHGRSDAT LNRNGVRMGS
ADIHDIVERL PEITEALVIG AEEPDGGYWM PLFVVPAPGV TVDDALRDRI RDAIRTSASP
RHVPDEILAV PAIPHTKTGK KLEVPVKRLL QGAPAEQVLN PAAVDNPDMV AHFARLGAER
SQQRVRTQAR LHPVEDAS
//
