ID   A0A0M8VN13_9ACTN        Unreviewed;       819 AA.
AC   A0A0M8VN13;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=ADK64_05110 {ECO:0000313|EMBL:KOV69129.1};
OS   Streptomyces sp. MMG1121.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1415544 {ECO:0000313|EMBL:KOV69129.1, ECO:0000313|Proteomes:UP000037687};
RN   [1] {ECO:0000313|Proteomes:UP000037687}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MMG1121 {ECO:0000313|Proteomes:UP000037687};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOV69129.1}.
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DR   EMBL; LGDV01000038; KOV69129.1; -; Genomic_DNA.
DR   RefSeq; WP_053655214.1; NZ_LGDV01000038.1.
DR   AlphaFoldDB; A0A0M8VN13; -.
DR   STRING; 1415544.ADK64_05110; -.
DR   PATRIC; fig|1415544.3.peg.1065; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000037687; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KOV69129.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037687};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          22..477
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          781..807
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          449..476
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   819 AA;  89243 MW;  4CA2CD03DB3E5623 CRC64;
     MARRSTKTPP PDDSYEERIL DIDVVDEMRG SYLEYAYSVI YSRALPDARD GLKPVHRRIV
     YQMNEMGVRP DRAYVKCARV VGEVMGKLHP HGDASIYDAL VRMAQPFSMR VPLVDGHGNF
     GSLGNDDPPA AMRYTECRMA EATSLMTESI DEDTVDFTPN YDGQEQEPVA LPAAFPNLLV
     NGSSGIAVGM ATNMPPHNLR EVISAARHLI KYPNADLDTL MRHVPGPDLP TGGRIVGLDG
     IRDAYATGRG TFKMRATVSV EPVTARRKGL VVTELPFTVG PEKVIAKIKD LVNAKKIQGI
     ADVKDLTDRE HGLRLVIEIK NGFVPEAVLE QLYKLTPMEE SFGINNVALV DGQPLTLGLK
     ELLEVYLDHR FDVVRRRSEF RRGKRRDRLH LVEGLLTALV DIDEVIRLIR SSDNSAQAKE
     RLMERFSLSE IQTQYILDTP LRRLTKYDRI ELEAEKDKLT AEIEELTRIL ESDTELRKLV
     SAELAAVTKK FGTDRRTVLL ESAGTPVAAV SLQVADDPCR VLLSSTGLLA RTSTDEPFPE
     EADAKRVKHD VIVSAVPATA RGEIGAVTSA GRLLRINVVD LPQLPPTAAA PNLSGGAPLA
     EFVSLQDDET VVCLTTLDES SPGLALGTEQ GVVKRVVPDY PSNKDELEVI SLKEGDRIVG
     AVELRTGEED LVFISDDAQL LRFQASVVRP QGRPAGGMAG IKLVEGAKVI SFTAVDPAAD
     AVVFTVAGSR GTLDDSVQTT AKLTPFDQYP RKGRATGGVR CQRFLKGEDC LSLGWAGPAP
     ARAAQKTGTP AELPELDPRR DGSGTSLQKT VSVVAGPVF
//