ID A0A0M8VQ12_9ACTN Unreviewed; 378 AA.
AC A0A0M8VQ12;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=LacI family transcriptional regulator {ECO:0000313|EMBL:KOV70351.1};
GN ORFNames=ADL00_08910 {ECO:0000313|EMBL:KOV70351.1};
OS Streptomyces sp. AS58.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519489 {ECO:0000313|EMBL:KOV70351.1, ECO:0000313|Proteomes:UP000037758};
RN [1] {ECO:0000313|EMBL:KOV70351.1, ECO:0000313|Proteomes:UP000037758}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AS58 {ECO:0000313|EMBL:KOV70351.1,
RC ECO:0000313|Proteomes:UP000037758};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV70351.1}.
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DR EMBL; LGDU01000059; KOV70351.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8VQ12; -.
DR PATRIC; fig|1519489.3.peg.2072; -.
DR Proteomes; UP000037758; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06267; PBP1_LacI_sugar_binding-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF138; HTH-TYPE TRANSCRIPTIONAL REGULATOR KDGR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000037758};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 49..103
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
FT REGION 26..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 41012 MW; 4770E16BD6F3176D CRC64;
MSRLYARRHI LIQTIELRIP VDHRTGHHTV PETHRRADRL PGSRYGNRPT MKDVAARAGV
GLKTVSRVVN GEPGVTPETE RRVQEAIDAL GFRRNDSARV LRKGRTASIG LVLEDLADPF
YGPLSRAVEE VARAHGALLI NGSSAEDPDR EQELVLALCA RRVDGLVVIP AGDDHRYLEP
ELKAGVATVF VDRPAGKIDA DVVLSDSYGG ARDGVAHLIA HGHRRIGFIG DMPRIHTAAE
RLRGYRAAME DAGISVEDSW MSLGVTDPGR VRRATEEMLA GPDPVTAVFA GNNRVTVTVI
RVLAEQSRQV ALVGFDDIEL ADLLQPGVTV VAQDAAALGR TAAERLFRQL DGSLVLPERI
ELPTRLITRG SGELPPAD
//
