GenomeNet

Database: UniProt
Entry: A0A0M8W5V1_9NOCA
LinkDB: A0A0M8W5V1_9NOCA
Original site: A0A0M8W5V1_9NOCA 
ID   A0A0M8W5V1_9NOCA        Unreviewed;       720 AA.
AC   A0A0M8W5V1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   11-DEC-2019, entry version 15.
DE   RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE            EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN   Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN   ORFNames=ADL03_37165 {ECO:0000313|EMBL:KOV79369.1};
OS   Nocardia sp. NRRL S-836.
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia;
OC   unclassified Nocardia.
OX   NCBI_TaxID=1519492 {ECO:0000313|EMBL:KOV79369.1, ECO:0000313|Proteomes:UP000037746};
RN   [1] {ECO:0000313|EMBL:KOV79369.1, ECO:0000313|Proteomes:UP000037746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL S-836 {ECO:0000313|EMBL:KOV79369.1,
RC   ECO:0000313|Proteomes:UP000037746};
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC       Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC       least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC       Rule:MF_01488}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC   -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01488}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOV79369.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LGDY01000134; KOV79369.1; -; Genomic_DNA.
DR   RefSeq; WP_053738281.1; NZ_LGDY01000134.1.
DR   EnsemblBacteria; KOV79369; KOV79369; ADL03_37165.
DR   PATRIC; fig|1519492.3.peg.7936; -.
DR   Proteomes; UP000037746; Unassembled WGS sequence.
DR   GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01488; RecD_like; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR006345; DNA_helicase_RecD-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR029493; RecD-like_HHH.
DR   InterPro; IPR041451; RecD-like_SH13.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   Pfam; PF14490; HHH_4; 1.
DR   Pfam; PF18335; SH3_13; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR01448; recD_rel; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW   Helicase {ECO:0000256|HAMAP-Rule:MF_01488, ECO:0000313|EMBL:KOV79369.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037746}.
FT   DOMAIN          334..531
FT                   /note="AAA"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   NP_BIND         345..349
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ   SEQUENCE   720 AA;  78653 MW;  D174A9CDD1FB44BD CRC64;
     MNVLEAVLER ITYANEDNGY TVAKVDTGRG DLVTVVGALL GAQPGESIRM RGHWGSHPQY
     GKQFHVDDYT TVLPATIQGI RRYLGSGLIK GIGPVLADKI VTHFGTDALD VIEHTPERLV
     EVPKLGPKRT KLIADAWEEQ KAIKEVMVFL QGVGVSTSLA VRIYKQYADK AIDVVREEPY
     RLASDVWGIG FKTADVIAKA VGIPHDSPQR VKAGLQFTLS EATTDGNCYL PEQALIAEAI
     KILQVDTGLV IDCLAELVEE EGVVREELPD DEIAIYLVPF HRAEISMAAQ LKRLLHTDTD
     RMPSFRDVDW DKAFAWLGTE LEQHQAEAVK LALTQKVAVL TGGPGCGKSF TVRSIVRLAL
     AKRAKIVLAA PTGRAAKRLS ELTGHEARTV HRLLELKPGG DAAYDRDHPL DADLVVVDEA
     SMLDLLLANK LVKAVPPGAH LLLVGDVDQL PSVGAGEVLR DVLAQGSPVP NVRLTHIFRQ
     AQESGVVTNA HRINSGDYPV VQGLPDFFLF ATDEAEEAAT TTVDVVANRI PRRFGLDPRK
     DVQVLAPMHR GPAGAGSLNT VLQEALTPSR ENLPEKRFGG RVFRVGDKVT QIRNNYDKGR
     NGVFNGTLGV VTALDPVEQK LTIRTDEDED VDYEFSELDE LSHAYAMTIH RSQGSEYPCV
     VIPITTSAWM MLQRNLLYTA VTRAKKLVVL VGSKRAIGQA VRTVGAGRRH TALAHRLRTG
//
DBGET integrated database retrieval system