ID   A0A0M8WEA0_9NOCA        Unreviewed;       363 AA.
AC   A0A0M8WEA0;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:KOV83930.1};
GN   ORFNames=ADL03_18850 {ECO:0000313|EMBL:KOV83930.1};
OS   Nocardia sp. NRRL S-836.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1519492 {ECO:0000313|EMBL:KOV83930.1, ECO:0000313|Proteomes:UP000037746};
RN   [1] {ECO:0000313|Proteomes:UP000037746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL S-836 {ECO:0000313|Proteomes:UP000037746};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate
CC         + CO2 + NADH; Xref=Rhea:RHEA:32271, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:17865, ChEBI:CHEBI:35121, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.1.1.85;
CC         Evidence={ECO:0000256|ARBA:ARBA00000624};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOV83930.1}.
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DR   EMBL; LGDY01000097; KOV83930.1; -; Genomic_DNA.
DR   RefSeq; WP_053734776.1; NZ_LGDY01000097.1.
DR   AlphaFoldDB; A0A0M8WEA0; -.
DR   STRING; 1519492.ADL03_18850; -.
DR   PATRIC; fig|1519492.3.peg.4047; -.
DR   OrthoDB; 5289857at2; -.
DR   Proteomes; UP000037746; Unassembled WGS sequence.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR43275; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR   PANTHER; PTHR43275:SF1; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW   Leucine biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037746}.
FT   DOMAIN          4..341
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   363 AA;  39464 MW;  2F9FB06A4FBFFEAC CRC64;
     MVPTIGLAVG RGTGPELADV FERVLATLGE AWSVRIGLTR SPRLYHSYFS LRAEASGVEE
     VRLLTEQDAR HYEEFCREQA RAGTTAIFRT AINAQSLYLV RERLQAVKVD LIAGQGTELL
     LVRDEAQGFY TGENHHEPGI VRRTTTFSAE ITERVVLTAL RQAERYWPGE PVGPVVMAYK
     FHLLDGALGE WVADIGARHG VELRLAQPDT VNRNIIEHGL PARSVVIGAN EWADIMHVVL
     LDRLGCERQE NRCTENVHLH PAVSNLVEYQ TVHGSADDLE GLGVVNPTAT IRAAAAVAER
     HAGCAGAVAR VESALTVVSN QGVRTPDLGG RHSTGEVVAA VLELLREPGP RGRHAAVARA
     GEE
//