ID A0A0M8WKK1_9NOCA Unreviewed; 525 AA.
AC A0A0M8WKK1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Tyrosine ammonia-lyase {ECO:0000313|EMBL:KOV87530.1};
GN ORFNames=ADL03_06310 {ECO:0000313|EMBL:KOV87530.1};
OS Nocardia sp. NRRL S-836.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1519492 {ECO:0000313|EMBL:KOV87530.1, ECO:0000313|Proteomes:UP000037746};
RN [1] {ECO:0000313|Proteomes:UP000037746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL S-836 {ECO:0000313|Proteomes:UP000037746};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV87530.1}.
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DR EMBL; LGDY01000047; KOV87530.1; -; Genomic_DNA.
DR RefSeq; WP_053732408.1; NZ_LGDY01000047.1.
DR AlphaFoldDB; A0A0M8WKK1; -.
DR STRING; 1519492.ADL03_06310; -.
DR PATRIC; fig|1519492.3.peg.1330; -.
DR OrthoDB; 9806955at2; -.
DR Proteomes; UP000037746; Unassembled WGS sequence.
DR GO; GO:0016841; F:ammonia-lyase activity; IEA:InterPro.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR InterPro; IPR022314; Tyr_aminomutase.
DR NCBIfam; TIGR03832; Tyr_2_3_mutase; 1.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR Pfam; PF00221; Lyase_aromatic; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00488; PAL_HISTIDASE; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:KOV87530.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037746}.
FT ACT_SITE 54
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR622314-1"
FT BINDING 84
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR622314-2"
FT BINDING 196
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR622314-2"
FT BINDING 301
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR622314-2"
FT MOD_RES 144
FT /note="2,3-didehydroalanine (Ser)"
FT /evidence="ECO:0000256|PIRSR:PIRSR622314-3"
FT CROSSLNK 143..145
FT /note="5-imidazolinone (Ala-Gly)"
FT /evidence="ECO:0000256|PIRSR:PIRSR622314-4"
SQ SEQUENCE 525 AA; 55937 MW; 82972A62866ABFA4 CRC64;
MSLVEFDGEH LDIAGIRAVA ELGQECAVAP AALAKAAKSR AMFEDIARQN IPIYGVTTGY
GEMIYMRVDV AKEVELQTNL VRSHSAGVGP LFAVDEARAI VAARLNALAK GYSAVRPEVL
QRLALYLNSD ITPAIPEIGS LGASGDLAPL AHVASTVIGE GYVLRDGKPV STAEVLRAKG
IKPLELRFKE GLALINGTSA MTGLGSLVVA RALEQVRQAE IVTALMIEAL RGSTSPFLSE
GHDIARPHPG QIASAANLRA LLAGSLLTVE HADLRRELEE EHDGKDVQRT EVYLQKAYTM
RAIPQVAGAV RDTLHDAVRK LEIELNSSND NPLFFEGREI FHGANFHGQP IAFAMDYVTI
ALTQLGVLSE RQTNRLLNRH LNYGLPEFLV AGDPGLNSGF AGAQYPATAL VAENRTIGPA
STQSVPSNGD NQDIVSMGLI SARNARRVLS NNTRILAVQY LAAAQAVDVA ERRSGLSPQS
AATYSKVRSL VPTLAEDRFM ADDIEVVAAA VAAGEFVSAV GVELN
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