ID A0A0M8WUE4_9ACTN Unreviewed; 788 AA.
AC A0A0M8WUE4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Glycosyl hydrolase {ECO:0000313|EMBL:KOV92899.1};
GN ORFNames=ADL04_29425 {ECO:0000313|EMBL:KOV92899.1};
OS Streptomyces sp. NRRL B-3648.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519493 {ECO:0000313|EMBL:KOV92899.1, ECO:0000313|Proteomes:UP000037702};
RN [1] {ECO:0000313|EMBL:KOV92899.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-3648 {ECO:0000313|EMBL:KOV92899.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC {ECO:0000256|ARBA:ARBA00006768}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV92899.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LGDZ01000209; KOV92899.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8WUE4; -.
DR PATRIC; fig|1519493.3.peg.6261; -.
DR Proteomes; UP000037702; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR005194; Glyco_hydro_65_C.
DR InterPro; IPR005195; Glyco_hydro_65_M.
DR InterPro; IPR005196; Glyco_hydro_65_N.
DR InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11051:SF13; GLYCOSYL TRANSFERASE-RELATED; 1.
DR Pfam; PF03633; Glyco_hydro_65C; 1.
DR Pfam; PF03632; Glyco_hydro_65m; 1.
DR Pfam; PF03636; Glyco_hydro_65N; 1.
DR PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000313|EMBL:KOV92899.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037702}.
FT DOMAIN 2..257
FT /note="Glycoside hydrolase family 65 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03636"
FT DOMAIN 314..666
FT /note="Glycoside hydrolase family 65 central catalytic"
FT /evidence="ECO:0000259|Pfam:PF03632"
FT DOMAIN 685..743
FT /note="Glycoside hydrolase family 65 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03633"
FT REGION 745..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..769
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 475
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
FT BINDING 348..349
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
FT BINDING 579..580
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
SQ SEQUENCE 788 AA; 86036 MW; 6857EDC5E9E42236 CRC64;
MRETELNLDV LAQSESVFAL SNGHIGWRGN LDEGEPHGLP GAYLNGVYER HPLPYAEAGY
GYPESGQTMI NVTDGKIIRL LVDDHPCDLR YGRLHAHERV LDFRTGVLGR TAQWTTPGGR
TVRITTQRLV SFTQRAVAAI VYEVEPIDGP ATVAVQSELV ANAQLPRLHG DPRVAAAIES
PLVAEEHFAQ DTRLRLVHRT AHSALRVAAA ADHLVEGPGS THRTAESEPD VSRLTVTADL
VPGQPLRLVK FVAYGWSGER SLPAVHDQVD AAVAAAVSTG WDGLLAAQRA YLDRFWAGAD
VEVEGDAQIQ QAVRFALFHV LQAAVRSENR AIPAKGLTGT GYDGHSFWDT ESYVLPVLTF
TAPEAVASAL RWRHRMLPAA RERASQLGLS GAAFPWRTID GAESSAYWPA GTAAFHINAD
IAMAAVRYVM VTEDEDFERH EGLDLLVDTA RLWRSLGHHD AEGVFHIDGV TGPDEYSAIA
RDNVYTNLLA RQNLLAAADG IARHPDRAAE LGVDDEETAV WRDAATRMAV PYNESLGVHE
QSAGFTSLQR WDFEATPPGS YPLLLHYPYF DLYRKQVVKQ ADLVLAMMEC PHLFSEDQKA
RNFAYYEAIT VRDSSLSACC QAVLAAETGH LRLAYAYLGE AALMDLGDLE HNTRDGLHIA
SLAGTWIALV AGFGGLRRYI GGDGRPDRLA FAPRLPEALS RVAFSVLVRG RRLKVDIGPS
RARYRLVEGE PLVVLHHGEA MTLTTDEPLD RPMPPPTALP EPQQPPGRRP AGLPAGEEQQ
GGAVDQTP
//
