ID A0A0M8WWI4_9ACTN Unreviewed; 383 AA.
AC A0A0M8WWI4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein {ECO:0000313|EMBL:KOV94244.1};
DE EC=4.2.1.75 {ECO:0000313|EMBL:KOV94244.1};
GN ORFNames=ADL04_24160 {ECO:0000313|EMBL:KOV94244.1};
OS Streptomyces sp. NRRL B-3648.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519493 {ECO:0000313|EMBL:KOV94244.1, ECO:0000313|Proteomes:UP000037702};
RN [1] {ECO:0000313|EMBL:KOV94244.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-3648 {ECO:0000313|EMBL:KOV94244.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV94244.1}.
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DR EMBL; LGDZ01000197; KOV94244.1; -; Genomic_DNA.
DR RefSeq; WP_053710400.1; NZ_LGDZ01000197.1.
DR AlphaFoldDB; A0A0M8WWI4; -.
DR PATRIC; fig|1519493.3.peg.5130; -.
DR OrthoDB; 213853at2; -.
DR Proteomes; UP000037702; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR039793; UROS/Hem4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Lyase {ECO:0000313|EMBL:KOV94244.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037702}.
FT DOMAIN 279..372
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 279..372
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 383 AA; 40646 MW; 09B6CA0E3BDFC857 CRC64;
MYDEEQQPEH GPLAGFTVGV TAARRAEELG ALLQRRGATV LHAPALRIVP LADDGELLAA
TKEIIDQVPD VVVATTAIGF RGWVEAADGW GLGEQLLGRL RGVRLLARGP KVKGAIRAAG
LDEEWSPSSE SLAEVLDRLL EEGVDGDRVA VQLHGEPLPG FVESLRAAGA EVVPVPVYRW
MPPEDLGPLD RLLDAAVTRG LDALTFTSAP AAASLLSRAE DRGLLDELLA ALAHDVVPAC
VGPVTAIPLQ ARGVDTVQPE RFRLGPLVQL LCQELPSRAR SLPVAGHRVE IRGHAVVVDG
ELKPVPPAGM SLLRALAHRP GWVVPRADLL RALPGAGRDE HAVETAMARL RTALGAPKLI
QTVVKRGYRL ALDPAADAKY ADA
//
