ID A0A0M8XJ67_9ACTN Unreviewed; 725 AA.
AC A0A0M8XJ67;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:KOX07302.1};
GN ORFNames=ADL05_29095 {ECO:0000313|EMBL:KOX07302.1};
OS Nocardiopsis sp. NRRL B-16309.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1519494 {ECO:0000313|EMBL:KOX07302.1, ECO:0000313|Proteomes:UP000037694};
RN [1] {ECO:0000313|Proteomes:UP000037694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16309 {ECO:0000313|Proteomes:UP000037694};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate;
CC Xref=Rhea:RHEA:22088, ChEBI:CHEBI:30616, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:142410, ChEBI:CHEBI:456215; EC=2.7.6.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001157};
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOX07302.1}.
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DR EMBL; LGEC01000148; KOX07302.1; -; Genomic_DNA.
DR RefSeq; WP_053620200.1; NZ_LGEC01000148.1.
DR AlphaFoldDB; A0A0M8XJ67; -.
DR STRING; 1519494.ADL05_29095; -.
DR PATRIC; fig|1519494.3.peg.6354; -.
DR OrthoDB; 9805041at2; -.
DR UniPathway; UPA00908; UER00884.
DR Proteomes; UP000037694; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015970; P:guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KOX07302.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000037694};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KOX07302.1}.
FT DOMAIN 46..143
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 387..450
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 651..725
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 725 AA; 81657 MW; 5C59A430637F3164 CRC64;
MNPVLEPLIK TVRATHPKVD VRLIERAYEV AAHHHRDQKR KSGDPYITHP LAVATILAEL
GMQEATLAAA LLHDTVEDTE YSLDELRADF GDEIAELVDG VTKLDKVKYG EATQAETVRK
MVVAMARDIR VLVIKLCDRL HNMRTLRYLP SKAKREKKAR ETLEIFAPLA HRLGMNTIKW
ELEDLAFATL YPKRFDEIAR LVSERAPRRD VYLQEVIEAV SADLRESKLK ATVRGRPKHY
YSIYQKMIAR NCGFDEIYDL IAVRVLVDSV RDCYAALGTI HARWNPVPGR FKDYIAMPKF
NMYQSLHTTV IGPSGNPVEL QIRTRAMHRR AEYGIAAHWK YKEDRGGGSE PKAKGTTDMQ
WLRQLIDWQQ ETKDPGEFLE SLRFDLSVQE VFVFTPQGDV ISLPQGATAV DFAYAVHTEV
GHRTVGARIN GRLVPLENEL HNGEAVEILT SKDPDAGPSR DWLNFVKSAR ARNKIRHWFT
KERREAAIEQ GKDEIAKVMR KQELPVKRMF SGEALIALAS DLRYPDVDSL YAAVGEHQVS
AQNVVSKLVD SMGGLESHTE DIAESALPGR TAVRRTKTGN PGVVVEGDSD VWVRLSKCCT
PVPGDDIVGF VTRGNGVSVH RADCVNAKTL DTERMVAVQW RPTEDSMFLV ALQVEALDRS
RLLSDITRVL SDQHVNILSA TVQTSRDRVA QSRFTFEMAD PAHLGSVLRA VRGVDGVYDV
YRVRN
//