ID   A0A0M8XMJ7_9ACTN        Unreviewed;       416 AA.
AC   A0A0M8XMJ7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Sodium:proton exchanger {ECO:0000313|EMBL:KOX08578.1};
GN   ORFNames=ADL04_03525 {ECO:0000313|EMBL:KOX08578.1};
OS   Streptomyces sp. NRRL B-3648.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1519493 {ECO:0000313|EMBL:KOX08578.1, ECO:0000313|Proteomes:UP000037702};
RN   [1] {ECO:0000313|EMBL:KOX08578.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL B-3648 {ECO:0000313|EMBL:KOX08578.1};
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOX08578.1}.
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DR   EMBL; LGDZ01000029; KOX08578.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M8XMJ7; -.
DR   PATRIC; fig|1519493.3.peg.797; -.
DR   Proteomes; UP000037702; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR   PANTHER; PTHR32468:SF0; K(+)_H(+) ANTIPORTER 1; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037702};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        60..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        127..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        160..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        307..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        341..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          10..393
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   416 AA;  43977 MW;  9A822AB8C5EAA7CC CRC64;
     MFALFSDLAL ILVLAQLLGA AARRFSQPAV IGEVLAGIML GPTLLGHRAS DFLFPTDIRP
     MLTALADVGM AVFMFIVGLE LDGKILRGTG RLAATVSLSS ILLPFGLGAL LALLLVEENA
     PDHRLGFVLF MGTAMSVTAF PVLARILTDR KMQHTPVGGL ALACAAIGDV LAWCMLAAVV
     ALAGGGGAHQ WYLLLLVPYT GVMLWVVRPL LRKLLTSGDG TARLSPAALT AVLAGLLVSG
     AVTEKMGLHF IFGAFFFGLV MPKESTERLR ADITDRVGHV SSHLLLPVFF ISVGLKVDLS
     DLGRSGWLDF ALVLLVAVSG KFLGAFLSAR AHGVTARQSA VLATLMNTRG LTELIILTAG
     LQLGVLNERL YSLMVAMAVV TTAMAGPLLS VLMPRPLTEH HLVRPARDAQ PPAAKR
//