ID A0A0M8XYY5_9PSEU Unreviewed; 577 AA.
AC A0A0M8XYY5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:KOX15932.1};
GN ORFNames=ADK67_40910 {ECO:0000313|EMBL:KOX15932.1};
OS Saccharothrix sp. NRRL B-16348.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1415542 {ECO:0000313|EMBL:KOX15932.1, ECO:0000313|Proteomes:UP000037722};
RN [1] {ECO:0000313|EMBL:KOX15932.1, ECO:0000313|Proteomes:UP000037722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16348 {ECO:0000313|EMBL:KOX15932.1,
RC ECO:0000313|Proteomes:UP000037722};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOX15932.1}.
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DR EMBL; LGED01000249; KOX15932.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8XYY5; -.
DR STRING; 1415542.ADK67_40910; -.
DR PATRIC; fig|1415542.3.peg.8803; -.
DR Proteomes; UP000037722; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
FT DOMAIN 1..170
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 173..269
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 299..476
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 479..575
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 577 AA; 61186 MW; 00B041BA7C526EAD CRC64;
MGAGIAEVLA RTGITVVAVD VDDAGLARGR GHLDHSTDRA VAGGKLSSDE RDATLGRISY
ATSLDALAGV DLVIEAVPER MELKAAVFAE LDRICGPDTV FASNTSALSI TEIGVHTGRP
GKVVGLHFFN PAPVLKLVEV IRTVVTEPDV VTDVVAFAEG LGKTPVVIGD RAGFIANALL
FGYLNHAVRM YETRYATRED LDAAMRYGCG YPMGPLAVLD LIGLDTAYEI LDTMYHQSRN
RLHAPAPLLK QMITAGLLGR KSGRGFYTYD GPDSPVVVPD VLTPVASAED DAAREVQRVG
VIGTGTMATG IVEVFAKRGY DVVLRARSEE KAAAAVGKVR KSLEKAVSRG RLSAEDRDAA
LARVTPVVDF AGLADCDLVV EAVAEELSIK KAVFEALDEV CKPGAVLATT TSSLPVIECA
AATARPGDVV GLHFFNPAQV MKLVEVVETI STSADVVATA RRVCLDLGKV PVHCGDRAGF
IVNALLFPYL NDAVKMLEAH YASADDIDNA MKVGCSLPMG PFELLDVVGL DVSLAIERSL
YLEFREAGFS PAPLLEHLVK AGRLGRKTGK GFRDYVA
//
