ID A0A0M8ZSK8_9HYME Unreviewed; 1581 AA.
AC A0A0M8ZSK8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Low-density lipoprotein receptor-related protein 6 {ECO:0000313|EMBL:KOX68763.1};
GN ORFNames=WN51_07256 {ECO:0000313|EMBL:KOX68763.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX68763.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX68763.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX68763.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX68763.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KQ435916; KOX68763.1; -; Genomic_DNA.
DR STRING; 166423.A0A0M8ZSK8; -.
DR OrthoDB; 3107655at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF00058; Ldl_recept_b; 10.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS51120; LDLRB; 12.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:KOX68763.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KOX68763.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1365..1387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 66..111
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 112..154
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 155..200
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 201..243
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 379..421
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 422..464
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 465..509
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 510..552
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 622..637
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 684..726
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 727..769
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 770..812
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1081..1123
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1444..1581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1550..1568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1280..1295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1298..1310
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1581 AA; 177781 MW; FCB9F33521CDAD5F CRC64;
MAVISLIIIL TACFFKLVLF SNGSPTLLFI TQKDIRMANA SRTNKVATII KDLSEGAALD
FYFEHELVCW SDSGLEIIQC IQTNGTHTGE RTIIVNSSLI SPDGLACDWY TGKLYWTDGE
KNRIEVTSID GRHRKVLFWT DIYQPRAIAL VPMKSILFWT DWGDIPKIER AAMNGDPSTR
EVIISDDIFW PNGLTVDYEN ELVYWVDGRL KFIAVMDYYG RNKRKVIEQG LDYPFAVTFF
DHKLYWTDWK TWCVHSYDVR QNQAHPRELL HGEYIPGDIE VWDVRRQPYG SHPCEKNNGN
CSHLCLLSMT EPGYSCACPT GVKLVDNLTC AERPEELLLI VQRNEICRIS LDSPDYTNFV
LPLTGIKHAI AIDFDPVQEM LYWTDEEART IRRASLDGSN QENIITTEVE NPDGIAIDWL
ARNLYWTDTG TDRIEVARLN GTSRKVLINE DLIEPRAIAL APELGWMFWT DWNEKRPKIE
RSNLDGTERI LLVNKDIVWP NGIALDLARW KIYWCDAKTD KIEVCNMDGT DRREVITDNL
PHLFGLSLLG DYLYWTDWQR RSVDRAHKLT GGDREVIVDQ VPNVMGLKAV HLGKVNGTNP
CVKSNGGCSH LCLNRPGNKY ICACQIGYEL TKDKKTCVVP DAFMLFARKE NIGRISIENA
NNDNIIPLTG VKDASALDFN IADNRIYWTD VKLKTITRAF MNGSDIERVV DLGLEAPEGL
AIDWIAHNLY WSDTGTRRIE MVRLEGCSRK VLIWTNIVEP RCLALDPSRG HMYWTEGGNY
GSIERSHLDG THREIILSNI GRANGLTIDH LARKLYWADL YTPAIDSFDL RTKKRNAIIT
DNIVYPFSIT QYQDYIYWTD WNTGDIEKAN KTTGKNRVNI HNKLESVTDL LVFHASRQAG
WNPCALKNGN CTHLCIALPG ENESTSNFFK CECPTHYNLA EDNKTCIAPE NFMMYSLRNA
MFRFLPDTND CPDVVLRIQG LKHVRSIEFD PITQHIYWID GRTLSIRRTL ENKTHSSIMI
SGNSGHPVDL ALDSLGRLLF WSCAINDAIN VTKLDNGSAL GIVVKGDGEK PRNIAIHSER
RLLFWTDVGK KMRVMRSKMD GKERVVIATD LEQPTSIAVD AMSNIVYWAH GNKIEYADFD
GNNGGILVST IGQGSTVYLS VFFDFIYWFD KETSNLERIN KSGNERKVIM NKVLTDLIAV
DTPQDDIMKT HICSPFRDYG GCSHFCIGTT SSKCSCPKSL VLSEDEKTCR AAPACGTDHF
TCAAPSSAVT KDCIPATWKC DGQTDCPDGS DELGCPACSR DQFKCQSGHC IDMSWVCDGT
AQCHDAVCDG WEDCADGSDE LPSACTPANN PRQENNSLES GRINYVIIIP IVLFAAIIAT
FSGFCYCKRR FMNNEELPDI LHDSAGDPLS PKPVRLAKPM FAQKNCRKDL KIGMETVRMS
MLNGSSVGSS YDRSHITGAS SSTRGSSTGG YPQETLNPPP SPATTANSTR CSSSNASRYK
PYRHYRSINQ PPPPTPCSTD VCDESDSNYP ARYRYESEPY PPPPTPRSVY QSDAGISCPP
SPSSRSSTYF SPLPPPPSPV P
//
