ID   A0A0M8ZSQ7_9HYME        Unreviewed;       970 AA.
AC   A0A0M8ZSQ7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Insulin-degrading enzyme {ECO:0000313|EMBL:KOX69206.1};
GN   ORFNames=WN51_06626 {ECO:0000313|EMBL:KOX69206.1};
OS   Melipona quadrifasciata.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Anthophila; Apidae; Melipona.
OX   NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX69206.1, ECO:0000313|Proteomes:UP000053105};
RN   [1] {ECO:0000313|EMBL:KOX69206.1, ECO:0000313|Proteomes:UP000053105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0111107301 {ECO:0000313|EMBL:KOX69206.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KOX69206.1};
RA   Pan H., Kapheim K.;
RT   "The genome of Melipona quadrifasciata.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; KQ435897; KOX69206.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M8ZSQ7; -.
DR   STRING; 166423.A0A0M8ZSQ7; -.
DR   OrthoDB; 129328at2759; -.
DR   Proteomes; UP000053105; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 5.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          34..171
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          198..376
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          383..627
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          637..820
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   970 AA;  112927 MW;  0CC8B91EC545E9EE CRC64;
     MDLHNFIEKR YDNIVKSPND KREYRGLLLF NKMRVLIISD PSTDKSAAAL NVNIGNLSEP
     DDLPGLAHFC EHMLFLGTEK YPEKNDYNKY LSQNGGTYNA STHMDHTLYY FDVHAEKLRG
     ALDRFAQFFI APLFTEALTE LELNAVHLEC EKNLANDTWR LDQLDKSSAD PKHPFSKFST
     GNKETLDVIP KQKGINVREK LLEFHDKFYS SNIMALSVLG KESLDELEQM IVELFSQVKN
     KDITVPTWPQ HPFNPKEHFQ HKWYVVPIKD IRNLHIIFPI PDLREHYKAA PAHYISHLLG
     HEGEGSLLSL LKAKGWCNSL GSGKRLGARG FSFFAVFVDL TEEGIQHVDD IVLLTFQYIN
     MLKKHGSVEW IYNEYRDIAN INFRFKEKGY PCDYTTGIAQ ILYDYPMEEI LIAEHLFPLW
     KPDLITWVME YLKPENVRVH VVAKLYENIT DESEKWYGVK FKKEKISQNI ISKWIDAGLN
     SDLNLPPKNE FILEKFDIKP AESTISKFPI IIEDTSLIRL WFKQDDEFLI PKANLFIDFV
     SPLAYMDPFS CNLTYIFVLL FRDALNEYAY AADIVGLKWE LTNSKYGMTL GIVGYDDKQH
     VLLNKIIDKM INFKVDPKRF EIWKENVCVV TFYVYYLTVE KVQNFIPQFL SKIHMECLIH
     GNITMSEAIE TAKSIESKLS NALPHMVPLP SRQLILHREI KLEDGCQFLF ETKTKFHSSS
     CTQVYYQTGL QSTESNMLLE LLAQILSEPC FTTLRTKEQL GYIVFSGVRR TNGAQGLRII
     VQSDRHPKYV EQRINMFLNS MLQHILTMTE EEFYAHKESL AIRRLEKPKQ MTALSAIFWS
     EITSQQYNFD RANIEVGYLR TITQEQILKF YKEIFQNDVQ RKLSVHVLST LKESKLEDED
     VIESNEDISS SDETNIAEQK KIDDILSFKI SQCLYETIQR YTKERNTFIK TMKCLLIIMS
     MCFNYVIVSD
//