ID   A0A0M9A1N8_9HYME        Unreviewed;       438 AA.
AC   A0A0M9A1N8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Glycine receptor subunit alpha-3 {ECO:0000313|EMBL:KOX73989.1};
DE   Flags: Fragment;
GN   ORFNames=WN51_14068 {ECO:0000313|EMBL:KOX73989.1};
OS   Melipona quadrifasciata.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Anthophila; Apidae; Melipona.
OX   NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX73989.1, ECO:0000313|Proteomes:UP000053105};
RN   [1] {ECO:0000313|EMBL:KOX73989.1, ECO:0000313|Proteomes:UP000053105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0111107301 {ECO:0000313|EMBL:KOX73989.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KOX73989.1};
RA   Pan H., Kapheim K.;
RT   "The genome of Melipona quadrifasciata.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KQ435794; KOX73989.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M9A1N8; -.
DR   STRING; 166423.A0A0M9A1N8; -.
DR   OrthoDB; 4265336at2759; -.
DR   Proteomes; UP000053105; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProt.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   CDD; cd18992; LGIC_ECD_HisCl; 1.
DR   CDD; cd19049; LGIC_TM_anion; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   PANTHER; PTHR18945:SF598; HISTAMINE-GATED CHLORIDE CHANNEL ALPHA1 SUBUNIT; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KOX73989.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        209..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        414..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          17..205
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
FT   DOMAIN          213..294
FT                   /note="Neurotransmitter-gated ion-channel transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF02932"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KOX73989.1"
SQ   SEQUENCE   438 AA;  49919 MW;  116145EAA28DC18F CRC64;
     RRSLEFFDLL PEDPKLYDKM RPPKKDGQAT VVYFHVTVMG LDSIDETSMT YAADIFFAQT
     WKDNRLRLPE NMTSEYRLLE VDWLKNMWRP DSFFKNAKSV TFQTMTIPNH YLWLYKDKTI
     LYMVNLTLKL SCAMNFLIYP HDTQELSHTT DEMIFQWDPD VPLVVDENIE LPQLQLVKNY
     TADCTQVYST GNFTCLEVIF VLKRRLGYYL FHTYVPTCLI VIMSWVSFWI KPEAAPARVT
     LGVTSLLTLS TQHAKSQASL PPVSYLKAVD AFMSVCTIFV FMALMEYCLV NIVLGDSDAP
     PKPAPPPPPP SSSCSDAAKL DKIFDIATKK KRSPPTGKFE NRSPFIVDHA FISPRLRGTE
     ALSAQRAVQV VIVVTQENAI LLSGRSQKPT TAGPPPGPTP AQKARMRALN IDRVSRVFFP
     FLFAVLNVTY WIMFAEYI
//