ID A0A0M9A381_9HYME Unreviewed; 809 AA.
AC A0A0M9A381;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=WN51_13480 {ECO:0000313|EMBL:KOX74919.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX74919.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX74919.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX74919.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX74919.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; KQ435776; KOX74919.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M9A381; -.
DR STRING; 166423.A0A0M9A381; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053105}.
FT DOMAIN 339..518
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 572..727
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 93010 MW; D5BB088473A8034E CRC64;
MGPPKRFKKD NDRGKWKKRK EDPEEYNDDD TLDDNETEGI PDAAKNDVEK QDDTALEDEF
GAKDYRTQMV LKPDCSLRPL WVAPNGHIFL ESFSPVYKHA HDFLIAISEP VCRPEHIHEY
KLTAYSLYAA VSVGLQTHDI IEYLKRLSKT TVPDGIIEFI KLCTLSYGKV KLVLKHNKYF
VESPYPEVLQ KLLKDPVIQE CRLKNTVEDE IITNIQNKTK APQFGAKAVT NVPTGVTKVT
ETNDQVPAEA AAVPEDITTF YDKMDKEDED EEEEHELKTV SFEVNQEKIE IIQKRCIELE
YPLLAEYDFR NDTVNPDINI DLKPSAVLRP YQEKSLRKMF GNGRARSGVI VLPCGAGKSL
VGVTACCTVR KRALVLCNSG VSVEQWKQQF KMWSTADDSM ICRFTSEAKD KPMGCGILIT
TYSMITHTQK RSWEAEQTMR WLQEQEWGIM VLDGNILFQF FFHNLTCIMC LEVHTIPAKM
FRRVLTIVQS HCKLGLTATL LREDDKIADL NFLIGPKLYE ANWLELQKRG FIARVQCAEV
WCPMTPEFYR EYLGCKMSKK LLLYVMNPNK FRCCQYLIRY HERRGDKTIV FSDNVFALKH
YAIKMNKPYI YGPTSQSERI QILQNFKFNT KVNTIFVSKV ADTSFDLPEA NVLIQISSHG
GSRRQEAQRL GRILRAKKGA IAEEYNAFFY TLVSQDTMEM NYSRKRQRFL VNQGYAYKVI
TKLAGMEEEP DLMYTSREEQ GHLLQQVLSA SDMDADEERI PGEGLRPIVR KAGNMTSMSG
ADDAVYYEYK KAPSSSTANK HPLFKKFRA
//
