ID   A0A0M9A524_9HYME        Unreviewed;      1098 AA.
AC   A0A0M9A524;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 10 {ECO:0000313|EMBL:KOX76103.1};
GN   ORFNames=WN51_11818 {ECO:0000313|EMBL:KOX76103.1};
OS   Melipona quadrifasciata.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Anthophila; Apidae; Melipona.
OX   NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX76103.1, ECO:0000313|Proteomes:UP000053105};
RN   [1] {ECO:0000313|EMBL:KOX76103.1, ECO:0000313|Proteomes:UP000053105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0111107301 {ECO:0000313|EMBL:KOX76103.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KOX76103.1};
RA   Pan H., Kapheim K.;
RT   "The genome of Melipona quadrifasciata.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00068}.
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DR   EMBL; KQ435753; KOX76103.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M9A524; -.
DR   STRING; 166423.A0A0M9A524; -.
DR   OrthoDB; 5395001at2759; -.
DR   Proteomes; UP000053105; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR   InterPro; IPR049038; ADAM10_Cys-rich.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   PANTHER; PTHR45702; ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR45702:SF3; KUZBANIAN-LIKE, ISOFORM A; 1.
DR   Pfam; PF21299; ADAM10_Cys-rich; 1.
DR   Pfam; PF13574; Reprolysin_2; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
PE   4: Predicted;
KW   Integrin {ECO:0000313|EMBL:KOX76103.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        457..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          196..332
FT                   /note="Disintegrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50214"
FT   REGION          490..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          567..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          668..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1098 AA;  124331 MW;  ADCB5A434F2E824C CRC64;
     MSETTEWRLK RQDISANLLF LFQKQCGKNH SKDMINSQLF APSFALVVYK EDYDAFCLSY
     MFTYRDFEKG TLGLAWTGDL KNAGGVCEKN GVSCRQWGNV TKLIRPWHHP VSHVTLAHEI
     GHNFGSPWKI CGASPEFLAP QNEFRGPQIP RKANSRTLGQ FPMPQNEFCC PQIFHKAVKL
     GRNFLMHKVG GKKPQNAICG NGVVEDGEEC DCGWEEDCND PCCHPQRLHH APHEVPCRLA
     DGAVCSPSQL IPSQGARDTR NMCFMTEYCD EMKFLKLDQN IILLIQPCNG PCCTSGCTLR
     NGDKCRDDNG CRDASFCDGR GPQCPPSINK PNKTICNEEF VCYMGGYARR LTLYAYGLES
     CQCIAGPDDP PTKSCELCCK LPGEDQPCLS SFAWNSAPYD IPDMLSKPGT PCNDYNGYCD
     VFQRCREVDP SGPLATLRRL LSDASLASFQ RWMVNRWYIV AATVLLSLSI VAFVAYSVSK
     RRNSRVKVPA TARDDQPRAA CEATNTSDEA ARGSSSVRKI RSMDISWVKR RIVETMKSIA
     SPRRKKDASA RAGTFFTRIS RLLARGSATA ASEEQSSNEA EQLCDGTRNA AKRGDENERL
     VIVSRDEGNV WRRVRVLFVG NRWKRASSSS PGRRKLSKGE TTCGAAWRKT VQVEKLCTGT
     SKVIVSSRRR GDRCQTEPLV VPDTPDTPGE TSENRSHTSD LTVLLADNEL LHQALQRVLA
     LRLSLLRLLQ RLRRQTSTTG GLASSRRQHP AAATGLLGQQ LSLKLLRLVV SDRDQLRGFH
     PHRGCGGGRC RCVAQLHLLL RVMTGQASLM TGKRMYADVR QPAGRTARRG QSDFFWKYVP
     FVWMVLAKGA RFLIRIHRPG GIGDALPCDV LAKLLEHRRV LLHADHGPRH QFLVRPHRHV
     PRLYPHEVVK HLTYKRTNNS RIYFSLHILF IEFVRKPSDL NETRDNRLIK GQDSYLREHR
     FSVMRDHNAV ITVEGYAVQL ANIDDLRSHD RSTGLFCLAY PKAVDSRIIT QHSNYTLDEF
     TWIETIEQGL YFKLIGELNV TEQSIVCYRR FPRILEKIKI EFTLRKKFYV IKKDVNTHSC
     YKFYQYNRNT KLTKFNVV
//