ID A0A0M9CCJ9_9ACTN Unreviewed; 584 AA.
AC A0A0M9CCJ9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=ISGA_08485 {ECO:0000313|EMBL:KOY49706.1};
OS Gordonia sp. NB41Y.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=875808 {ECO:0000313|EMBL:KOY49706.1, ECO:0000313|Proteomes:UP000011989};
RN [1] {ECO:0000313|EMBL:KOY49706.1, ECO:0000313|Proteomes:UP000011989}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NB4-1Y {ECO:0000313|EMBL:KOY49706.1,
RC ECO:0000313|Proteomes:UP000011989};
RX PubMed=23744905; DOI=10.1099/mic.0.068932-0;
RA Van Hamme J.D., Bottos E.M., Bilbey N.J., Brewer S.E.;
RT "Genomic and proteomic characterization of Gordonia sp. NB4-1Y in relation
RT to 6 : 2 fluorotelomer sulfonate biodegradation.";
RL Microbiology 159:1618-1628(2013).
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOY49706.1}.
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DR EMBL; APHK02000050; KOY49706.1; -; Genomic_DNA.
DR RefSeq; WP_053777002.1; NZ_CP132196.1.
DR AlphaFoldDB; A0A0M9CCJ9; -.
DR STRING; 1241906.ISGA_08485; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000011989; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 2.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KOY49706.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011989};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KOY49706.1}.
FT DOMAIN 13..85
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 119..277
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 326..556
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 61473 MW; E3A19A110202CBB0 CRC64;
MSRTTKKANP GRILFVGSGP GDPDLLTVRA RSVITSATTA YVDPDVPATV VAMIGADHRE
QPADDQRRST SKAKKDQAAK DQAKADATTT DDATSSTGAD ATTGDAKAPD AKAADTKSAE
KSAEEPEDQI VRPALGDPSE VAKTLVAAAK AGDDVVRVVS GDPLTTDSVL AEVNAVARTS
VTFEVLPGLP AASVVPSYAG MPLGSRHTEA DVRAEGVDWA ALAAAPGPLV LHATSGHLAE
TASALTEHGL APQTPVAITI NGTTCAQRTI EATLATLNEQ GNALTGPLIL TIGQVVTQRG
KLSWWESRAL YGWTVLVPRT KDQAADMSDR LVSHGAIPKE VPTIAVEPPR SPAQMERAVK
GLVDGRYQWV VFTSTNSVRA VWEKFAEFGL DARAFSGVKI ACVGEATAAK VRAFGINPEL
VPSGEQSSLG LLEDFPPYDD VFDPVDRILL PRADIATETL SEGLRERGWE IDDVTAYRTV
RAAPPPAQTR EMIKTGGFDA VCFTSSSTVR NLVGIAGKPH ARTIVACIGP KTAETATEFG
LRVDVQPENA SVTELVDALA EHAARLRAEG ALPPPRKKTR RSRS
//
