ID A0A0M9DBS0_9LACO Unreviewed; 382 AA.
AC A0A0M9DBS0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) {ECO:0000256|ARBA:ARBA00038858};
DE EC=5.1.3.14 {ECO:0000256|ARBA:ARBA00038858};
GN ORFNames=RZ71_00140 {ECO:0000313|EMBL:KOY75596.1};
OS Apilactobacillus kunkeei.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Apilactobacillus.
OX NCBI_TaxID=148814 {ECO:0000313|EMBL:KOY75596.1, ECO:0000313|Proteomes:UP000037778};
RN [1] {ECO:0000313|EMBL:KOY75596.1, ECO:0000313|Proteomes:UP000037778}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LAko {ECO:0000313|EMBL:KOY75596.1,
RC ECO:0000313|Proteomes:UP000037778};
RX PubMed=25953738; DOI=10.1093/gbe/evv079;
RA Tamarit D., Ellegaard K.M., Wikander J., Olofsson T., Vasquez A.,
RA Andersson S.G.;
RT "Functionally Structured Genomes in Lactobacillus kunkeei Colonizing the
RT Honey Crop and Food Products of Honeybees and Stingless Bees.";
RL Genome Biol. Evol. 7:1455-1473(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:68623; EC=5.1.3.14;
CC Evidence={ECO:0000256|ARBA:ARBA00036080};
CC -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC {ECO:0000256|ARBA:ARBA00038209, ECO:0000256|RuleBase:RU003513}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOY75596.1}.
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DR EMBL; JXCY01000007; KOY75596.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M9DBS0; -.
DR PATRIC; fig|148814.15.peg.951; -.
DR Proteomes; UP000037778; Unassembled WGS sequence.
DR GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR InterPro; IPR029767; WecB-like.
DR NCBIfam; TIGR00236; wecB; 1.
DR PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR PANTHER; PTHR43174:SF2; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003513};
KW Reference proteome {ECO:0000313|Proteomes:UP000037778}.
FT DOMAIN 32..367
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
SQ SEQUENCE 382 AA; 42963 MW; B8CEC25FB6AEF61D CRC64;
MKKPIKVMTI FGTRPEAIKM APIILEMKNN LDEFQPITVL TGQHKEMLDQ VMDIFHIEAD
YNLHVMKAQQ TLSSITTTVI NKLDSIINEA KPDIILVHGD TTTTFAAAVS AFYHQIPLGH
VEAGLRTWDK YSPYPEEMNR QMTDILSDVY FAPTELSKEN LLKQNLKEDR IYITGNTAID
ALKQTVDRNY HHSVLDDIDK THKIILLTMH RRENQGEPMR RTFETIKNEV LNRKDIEVVY
PVHLSPAVQS VAHSVFDGVN RVHLIEPLDV VDFHNMAARS HFIMTDSGGV QEEAPSLGKP
VLVLREATER PEGVDAGTLK LVGTDPEKIS ASIDQLLDDS EEYKKMATAK NPYGDGTASK
QILEAIKEVF ATNKLSGDHN EA
//
