ID A0A0M9EFR4_9RHOB Unreviewed; 319 AA.
AC A0A0M9EFR4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000313|EMBL:KPA20760.1};
DE EC=4.3.3.7 {ECO:0000313|EMBL:KPA20760.1};
GN Name=dapA_1 {ECO:0000313|EMBL:KPA20760.1};
GN ORFNames=shim_30070 {ECO:0000313|EMBL:KPA20760.1};
OS Shimia sp. SK013.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae.
OX NCBI_TaxID=1389006 {ECO:0000313|EMBL:KPA20760.1, ECO:0000313|Proteomes:UP000037951};
RN [1] {ECO:0000313|EMBL:KPA20760.1, ECO:0000313|Proteomes:UP000037951}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK013 {ECO:0000313|EMBL:KPA20760.1,
RC ECO:0000313|Proteomes:UP000037951};
RA Voget S., Kanukollu S., Daniel R., Engelen B.;
RT "Genome Sequence of Shimia sp. SK013.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPA20760.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LAJH01000016; KPA20760.1; -; Genomic_DNA.
DR RefSeq; WP_054003450.1; NZ_LAJH01000016.1.
DR AlphaFoldDB; A0A0M9EFR4; -.
DR STRING; 1389006.shim_30070; -.
DR PATRIC; fig|1389006.3.peg.3096; -.
DR OrthoDB; 6142028at2; -.
DR Proteomes; UP000037951; Unassembled WGS sequence.
DR GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IEA:UniProtKB-EC.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000037951}.
FT ACT_SITE 136
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 164
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 209
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 319 AA; 34203 MW; 96A0E0D5CAB2893D CRC64;
MSKNVFTGTM PALMTPCKAD RTPDYDALVR KGHEMIAAGM SAVVYCGSMG DWPLLTDAER
MTGVKRLVDA GVPVVVGTGA INSKSAVAHA AHAQKVGAVG LMVIPRVLSR GASAAAQENH
FKAILTAAPD VPAIIYNSPV YGFATKADLF FALRAAHPNL IGFKEFGGKD DLRYAAEHIT
SRDDQVTLMV GVDTEVYHGF VNCGATGSIT GIGTALPKEA LLLAALSQKA ADGNAEARVR
ALELEEAFGV LASFDEGTDL VLYYKHLLVL NGEEEYRLHF VETDALSDAQ RRYCEAHYTQ
FRAWFADWSA QGGIIAQCM
//
