ID A0A0M9F2T0_FUSLA Unreviewed; 1436 AA.
AC A0A0M9F2T0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=FLAG1_02178 {ECO:0000313|EMBL:KPA44873.1};
OS Fusarium langsethiae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=179993 {ECO:0000313|EMBL:KPA44873.1, ECO:0000313|Proteomes:UP000037904};
RN [1] {ECO:0000313|EMBL:KPA44873.1, ECO:0000313|Proteomes:UP000037904}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fl201059 {ECO:0000313|EMBL:KPA44873.1,
RC ECO:0000313|Proteomes:UP000037904};
RA Lysoe E., Divon H.H., Terzi V., Orru L., Lamontanara A., Kolseth A.-K.,
RA Frandsen R.J., Nielsen K., Thrane U.;
RT "The draft genome sequence of Fusarium langsethiae, a T-2/HT-2 mycotoxin
RT producer.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPA44873.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JXCE01000020; KPA44873.1; -; Genomic_DNA.
DR OrthoDB; 7041at2759; -.
DR Proteomes; UP000037904; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW Reference proteome {ECO:0000313|Proteomes:UP000037904}.
FT DOMAIN 41..429
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 508..670
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 718..809
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 822..1120
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1129..1321
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1396..1436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1436
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1436 AA; 162831 MW; 96E8C63073A4E144 CRC64;
MPTVKRHKGS GAAKAQKQSD PKPKSTDGRP TPAEVEEEEH QFVQLARKHW LKSGKKPAKP
KVKNDVLKQN IWDVLEREGF QYKPLLLLES LQTLESYLWP GYTEEASNFH VLLIALITNV
KHREHLATWT LFEDRPADFS SLFRRLLSMM IDRTLSVTLR TQLLCFFIYA FQSLDCTLVR
KECAPLVSIG IWHNLSTEQA REASLEQLPH LRKAWKAAHK RYDAADEQNK ARLRFERSWL
YTLLLDFLGL LYTQNSKADQ VLYCERFTEF LTDLQSQLPT RRYVNALVQD LHIIPAAKLS
PMFNDEENIL LRDLQALLSH FTFFDINDQT GAQYSIKEAY DKHCESLAKL QRTALKHFRE
KLTVLALSNY GAVDQRQELE ALLQPLTDEE LMELVSLLGF RTAYPDSLNL SVDRKLLLEV
VLSNFERRKT FQEAAQHMSL APTEETLFDS SFQQAESYDG SHPMALPKLN LQYLSVGDFL
WRALVLYRCE SFYGVRKDVE TAIRRLRPES KRSDETNFAG FSKMAMPISK PAILEVVPPL
VGDDKPSTVR AEVSFDVRRL GEGVRREWDS LRQGDVVFLI AVEPSPTKSA SNGGESLSES
ERLGVITVRT AEIHQITDDK GRQVRDGAGS LDSKRRIQLK LDPHAYSKDA ERAAAGKPDV
YGKINLLLRR GRRENNFKPV LESIRNLVLS DVPLPEWLHE VFLGYGDPAG AYYKNLPNRE
RKVDFRDMFL DWQHLAESLP GKIIDPGDDV SGSFGPPYVL ESVEKQSEPP STKPSKKRRR
DADPALIAEI ETMKVSSYKP PSNGPYPIDH PKLNSVRFTP AQIEAITSGT QPGLTVIVGP
PGTGKTDVAT QVINNIYHNH PEQKTLLLAH SNQALNQLFA KIVALDIDER HLLRLGHGEE
DLDTEGNFSK HGRVESFLEN RDRYLLEVRK LATSLGAPGV HENSAETAGY FNNVYVVPAW
NRFQLVASDD ATTVSDIIEA FPFHAYFSDA PQPLFPPEGD KEQILEVAKG CYRHISKIFL
ELADALPFEI LRRDRDKANY LLTSEARIIA MTTTHAAIRR GEVASLGFHY DNVVMEEAAQ
VTEIETFLPL AMQKPRNGKI GLQRVVLCGD HFQNSPVIQS LAFRHYANLE QSLFSRLVRL
GVPTVALDQQ GRARGSIASL YQWRYPKLDN LPSVQTSPEF VKANAGFKYD YQFINVPDYK
GQGEAEPTPH FIQNLGEAEY AVAIFQYMRL LGYPAEKITI LTTYAGQRAL VKDVLSHRCA
RNSVFGLPKA VATVDKYQGE QNDYIILSLT RTSRVGYLRD VRRMTVALSR ARLGLYILGR
REVFEACTEL RPAFDLLLQR PDKLMLVTGE LWPTPREVTE ELGAVEGEVP MEGVEHLGQY
VFEMTKTKIK QLQEEQGEPI IEEEFEDGEG EYGNGDDDED EEDDVEADIL EVREGE
//
