ID A0A0M9UCQ6_9CHLR Unreviewed; 928 AA.
AC A0A0M9UCQ6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Aconitate hydratase {ECO:0000256|ARBA:ARBA00012926, ECO:0000256|RuleBase:RU361275};
DE Short=Aconitase {ECO:0000256|RuleBase:RU361275};
DE EC=4.2.1.3 {ECO:0000256|ARBA:ARBA00012926, ECO:0000256|RuleBase:RU361275};
GN ORFNames=ARMA_1540 {ECO:0000313|EMBL:GAP63117.1};
OS Ardenticatena maritima.
OC Bacteria; Chloroflexota; Ardenticatenia; Ardenticatenales;
OC Ardenticatenaceae; Ardenticatena.
OX NCBI_TaxID=872965 {ECO:0000313|EMBL:GAP63117.1, ECO:0000313|Proteomes:UP000037784};
RN [1] {ECO:0000313|EMBL:GAP63117.1, ECO:0000313|Proteomes:UP000037784}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=110S {ECO:0000313|EMBL:GAP63117.1,
RC ECO:0000313|Proteomes:UP000037784};
RA Kawaichi S., Yoshida T., Sako Y., Nakamura R.;
RT "Draft Genome Sequence of a Heterotrophic Facultative Anaerobic
RT Thermophilic Bacterium, Ardenticatena maritima Strain 110ST.";
RL Genome Announc. 3:e01145-15(2015).
RN [2] {ECO:0000313|Proteomes:UP000037784}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=110S {ECO:0000313|Proteomes:UP000037784};
RA Kawaichi S., Yoshida T., Sako Y., Nakamura R.;
RT "Draft Genome Sequence of a Heterotrophic Facultative Anaerobic Bacterium
RT Ardenticatena maritima Strain 110S.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the isomerization of citrate to isocitrate via cis-
CC aconitate. {ECO:0000256|RuleBase:RU361275}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336,
CC ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023501,
CC ECO:0000256|RuleBase:RU361275};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185, ECO:0000256|RuleBase:RU361275}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAP63117.1}.
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DR EMBL; BBZA01000116; GAP63117.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M9UCQ6; -.
DR STRING; 872965.SE16_00775; -.
DR InParanoid; A0A0M9UCQ6; -.
DR OrthoDB; 9764318at2; -.
DR Proteomes; UP000037784; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01586; AcnA_IRP; 1.
DR CDD; cd01580; AcnA_IRP_Swivel; 1.
DR Gene3D; 6.10.190.10; -; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR044137; AcnA_IRP_Swivel.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR006249; Aconitase/IRP2.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR NCBIfam; TIGR01341; aconitase_1; 1.
DR PANTHER; PTHR11670; ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER; 1.
DR PANTHER; PTHR11670:SF54; CYTOPLASMIC ACONITATE HYDRATASE; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF00694; Aconitase_C; 1.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|RuleBase:RU361275};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU361275};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU361275};
KW Lyase {ECO:0000256|RuleBase:RU361275, ECO:0000313|EMBL:GAP63117.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000037784}.
FT DOMAIN 77..592
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 722..849
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
SQ SEQUENCE 928 AA; 102661 MW; F7837F1ED80AE24D CRC64;
MTLPNPFGAK DTFETGSGPA VIYRLSRLEE EGLGTISRLP YSIRVLLESV LRQVDGFRVT
EEDVATLAGY DAKNVPAREV PYLPARVVLQ DFTGVPAVVD LAAMRSAMQR YGGDPTRINP
HIPADLVIDH SVQVDAFGSA YALFFNAERE YERNRERYTL LRWAQTAFDN FRVVPPATGI
IHQVNLEYLA KVVHLVEVNG ERVAFPDSLV GTDSHTTMIN GLGVLGWGVG GIEAEANMLG
QPIYMLIPEV VGFKLYGELP EGATATDLVL TITQMLRQKG VVGKFVEFYG PGVSKLSLAD
RATIANMAPE YGATMGFFPV DEETLRYLIG TGRSEELVDL VERYTKEQGL FRTDDAPEPV
YTDTLELDMG TVQPSVAGPK RPQDRILLKD IKRSFWLDMK KTFGREVDTT GIDPEVIEAL
ETGKELPTST ERTSLYKNHE VEFSIDDVDA HITHGSTVIA AITSCTNTSN PSVMIGAGLL
AKKAVERGLT VKPHVKTSLA PGSRVVSKYL EESGLLPFLE ALRFHIVGYG CTTCIGNSGP
LPEAIANAIT ENDLVVSAVL SGNRNFEGRI NPYVRANYLA SPPLVIAFAL AGTVDIDFEH
EPIGHDPNGQ PVYLRDIWPT QEEIRSYIRR ALKPEMYREE YANVFEGDEH WKALEIPKGK
IYEWDPNSTY IQEPPFFMDF PLDVPDLTPI RGARVLALLG DTITTDHISP AGPILVNSPA
GQYLLSKGVQ PKDFNTYGAR RGNHEVMMRG TFANVRLRNK LVPGKEGGWT VYFPTGEEMW
IYDAAMRYKQ DGTPLLVIAG KEYGTGSSRD WAAKGTYLLG IKAVIAESFE RIHRSNLVGM
GVLPLQFKEG ENAESLGLTG REVYDILGID NDLQPRQTLT VQATDSESGE TKTFEVIVRL
DTPVEVEYYR NGGILHTVLR NMLRESRN
//
