ID A0A0M9VSX4_9HYPO Unreviewed; 199 AA.
AC A0A0M9VSX4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=EKC/KEOPS complex subunit CGI121 {ECO:0000256|ARBA:ARBA00016009};
DE AltName: Full=EKC/KEOPS complex subunit cgi121 {ECO:0000256|ARBA:ARBA00015316};
GN ORFNames=ESCO_003333 {ECO:0000313|EMBL:KOS18192.1};
OS Escovopsis weberi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Escovopsis.
OX NCBI_TaxID=150374 {ECO:0000313|EMBL:KOS18192.1, ECO:0000313|Proteomes:UP000053831};
RN [1] {ECO:0000313|EMBL:KOS18192.1, ECO:0000313|Proteomes:UP000053831}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA de Man T.J., Stajich J.E., Kubicek C.P., Chenthamara K., Atanasova L.,
RA Druzhinina I.S., Birnbaum S., Barribeau S.M., Teiling C., Suen G.,
RA Currie C., Gerardo N.M.;
RT "The genome of the fungus Escovopsis weberi, a specialized disease agent of
RT ant agriculture.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC formation of a threonylcarbamoyl group on adenosine at position 37
CC (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC is probably involved in the transfer of the threonylcarbamoyl moiety of
CC threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as
CC an allosteric effector that regulates the t(6)A activity of the
CC complex. The EKC/KEOPS complex also promotes both telomere uncapping
CC and telomere elongation. The complex is required for efficient
CC recruitment of transcriptional coactivators. CGI121 is not required for
CC tRNA modification. {ECO:0000256|ARBA:ARBA00025043}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CGI121/TPRKB family.
CC {ECO:0000256|ARBA:ARBA00005546, ECO:0000256|RuleBase:RU004398}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS18192.1}.
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DR EMBL; LGSR01000022; KOS18192.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M9VSX4; -.
DR STRING; 150374.A0A0M9VSX4; -.
DR OrthoDB; 1437975at2759; -.
DR Proteomes; UP000053831; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2380.10; CGI121/TPRKB; 1.
DR InterPro; IPR013926; CGI121/TPRKB.
DR InterPro; IPR036504; CGI121/TPRKB_sf.
DR PANTHER; PTHR15840; CGI-121 FAMILY MEMBER; 1.
DR PANTHER; PTHR15840:SF10; EKC_KEOPS COMPLEX SUBUNIT TPRKB; 1.
DR Pfam; PF08617; CGI-121; 1.
DR SUPFAM; SSF143870; PF0523-like; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004398};
KW Reference proteome {ECO:0000313|Proteomes:UP000053831};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
SQ SEQUENCE 199 AA; 21739 MW; F95BE002B78E9E2A CRC64;
MTPLESLTLE HVPAHYAVHV CLFQDVQNPA FLHQQLLARN PDFEYAFIDA AAILSRIHLL
SAIFKAINTH HTGSLRTPNI HSETVVSLSP SSNIAEAYRR FGISQSTKSL IAIKISALSD
ADSGAEAVED RIWSHLGTHV AGTPAPLTDA NISLVSNLQT IRKNYKLNGL NWIEAIGDES
RKKSETEKLI VAALALRGI
//
