ID   A0A0M9WB18_9EURO        Unreviewed;      1044 AA.
AC   A0A0M9WB18;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=FAD-binding PCMH-type domain-containing protein {ECO:0000259|PROSITE:PS51387};
GN   ORFNames=ACN38_g11190 {ECO:0000313|EMBL:KOS37999.1};
OS   Penicillium nordicum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=229535 {ECO:0000313|EMBL:KOS37999.1, ECO:0000313|Proteomes:UP000037696};
RN   [1] {ECO:0000313|EMBL:KOS37999.1, ECO:0000313|Proteomes:UP000037696}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DAOMC 185683 {ECO:0000313|EMBL:KOS37999.1,
RC   ECO:0000313|Proteomes:UP000037696};
RA   Nguyen H.D., Seifert K.A.;
RT   "Genome sequencing of Penicillium nordicum.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the oxygen-dependent FAD-linked oxidoreductase
CC       family. {ECO:0000256|ARBA:ARBA00005466}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOS37999.1}.
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DR   EMBL; LHQQ01000279; KOS37999.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M9WB18; -.
DR   STRING; 229535.A0A0M9WB18; -.
DR   OrthoDB; 1608525at2759; -.
DR   UniPathway; UPA00057; UER00099.
DR   Proteomes; UP000037696; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0004631; F:phosphomevalonate kinase activity; IEA:InterPro.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:InterPro.
DR   GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.40.462.20; -; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR016166; FAD-bd_PCMH.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR006094; Oxid_FAD_bind_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005919; Pmev_kin_anim.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   PANTHER; PTHR42973; BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED; 1.
DR   PANTHER; PTHR42973:SF25; PHOSPHOMEVALONATE KINASE; 1.
DR   Pfam; PF01565; FAD_binding_4; 1.
DR   Pfam; PF04275; P-mevalo_kinase; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
DR   PROSITE; PS51387; FAD_PCMH; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037696}.
FT   DOMAIN          202..393
FT                   /note="FAD-binding PCMH-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51387"
FT   REGION          797..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1044 AA;  113740 MW;  385543A1E9EB288E CRC64;
     MEKWLCSTLE TESPLPCLES PPDIHRIPFD INGNAKSDTR TRGSDEKFDV ILLCHSMYGM
     KPKARFIERP LGMLVEHPEG GMVVVFHRDG TLHLDGLVCH RTASFPTGAV CVADDDEVLD
     SFAPFIAGFV MQDAEADKAI RVEWREVCRA LGRREKNHPD HLVFSSPNIM VAFNKHATTL
     PELTAQVSWL DGEKWVKNWE ARLHHPAAVV KPTEIRHVQQ CVQWALKHGF NLTVVGGGHS
     GHCLYPSVVS VDMSAFDQVH ILTAEDGRES GSNSAPWVIA EAGCKTGDII CKAMAAGLTV
     PLGARPSVGA GLWLQGGIGH LARMHGLACD SIVGAVMVSV ESGQLLSIGR VPSQHRPVGA
     VLPENESDLL WAIKGAGTNF GIVISVTFEA YAAPMFSIRN WVFQLSDNLE ARRKLSDFDD
     LVARKLPQNC SADAYLYWDI GQLHFGVTMF ESSTTELISE TPMSTPTPVE TILGPEDNLQ
     VVDGVGLFGT EMYMSGMHGG HTKSKTSSFK RCLFLKRIGA LNVAEILVAA IETRPSPLSY
     LHLLQGGGAI SDVPADATAF GCRDWDFACV VTGVWPRQQD GTEVARAAVQ WVYNVASNLL
     PVSSGVYGAD LGPDPRDTAL AAKAFGPNLP RLARLKRIAD RGNVLAYACP LPKAPTEQKL
     IILVTGASGA GKDHCANIWV SVFHECTQKR FMARVVSISD ATKREYAGAT GVDFNRLLLD
     REYKEQHRPA LTTYFQSQVQ HRPRLPEEHF LNVVYGAGDV DVLLITGMRD EAPVAAFSHL
     VPDSRLLDVR VKANKETRRA RRGCHGGDSD GDDNANGGPK PKPLDYSPSL VFNNDETGNE
     KAKMFAEDYL LPFFGKDLQR LRKMVRPVPD FPRPGVKFQH VLNISQHPGG LALCTGLLHA
     HFTGDWAKVD RIVCCEAGGF IYASALASQV NVPLALIREA GKLPPPTVSV LKNTSHISSA
     SNSNEKMIEI ERDLIPRGAS VVVVDDVLST GNTLCAVLQL LGEVGIADVS IMVVGEFPIH
     RGRQLLHQRE FGINIQSLLV FDGA
//